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The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling

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Science Translational Medicine  19 Sep 2018:
Vol. 10, Issue 459, eaat9356
DOI: 10.1126/scitranslmed.aat9356

Article Information

vol. 10 no. 459

PubMed: 
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History: 
  • Received for publication April 19, 2018
  • Accepted for publication August 31, 2018
  • .

Author Information

  1. Fabiana Csukasi1,
  2. Ivan Duran1,
  3. Maya Barad1,
  4. Tomas Barta2,
  5. Iva Gudernova3,
  6. Lukas Trantirek4,
  7. Jorge H. Martin1,
  8. Caroline Y. Kuo5,
  9. Jeremy Woods5,
  10. Hane Lee6,
  11. Daniel H. Cohn1,7,8,
  12. Pavel Krejci1,9,10,11 and
  13. Deborah Krakow1,7,12,13,*
  1. 1Department of Orthopaedic Surgery, University of California–Los Angeles, Los Angeles, CA 90095, USA.
  2. 2Department of Histology and Embryology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic.
  3. 3Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic.
  4. 4Central European Institute of Technology, Masaryk University, 62500 Brno, Czech Republic.
  5. 5Department of Pediatrics, University of California–Los Angeles, Los Angeles, CA 90095, USA.
  6. 6Department of Pathology and Laboratory Medicine, University of California–Los Angeles, Los Angeles, CA 90095, USA.
  7. 7Orthopaedic Institute for Children, University of California–Los Angeles, Los Angeles, CA 90095, USA.
  8. 8Department of Molecular, Cell and Developmental Biology, University of California–Los Angeles, Los Angeles, CA 90095, USA.
  9. 9Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic.
  10. 10International Clinical Research Center, St. Anne’s University Hospital, 65691 Brno, Czech Republic.
  11. 11Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 60200 Brno, Czech Republic.
  12. 12Department of Human Genetics, University of California–Los Angeles, Los Angeles, CA 90095, USA.
  13. 13Department of Obstetrics and Gynecology, University of California–Los Angeles, Los Angeles, CA 90095, USA.
  1. *Corresponding author. Email: dkrakow{at}mednet.ucla.edu

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