19 September 2018
Vol 10, Issue 459

About The Cover

Cover image expansion

ONLINE COVER Manipulating Metabolism. Shown here are crystals of the amino acid arginine, important for cellular metabolism. Li et al. discovered that arginine metabolism is disrupted in patients infected with severe fever with thrombocytopenia syndrome (SFTS) virus. This recently identified bunyavirus causes potentially fatal thrombocytopenia. The investigators then performed a randomized controlled clinical trial administering arginine to patients with SFTS, which led to reduced platelet activation and faster viral clearance. Their results not only shed light on pathogenesis of a fatal infection, but also could help pave the way for a targeted treatment. [CREDIT: DAVID PARKER/SCIENCE SOURCE]