Research ArticleHuntington’s Disease

Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington’s disease

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Science Translational Medicine  12 Sep 2018:
Vol. 10, Issue 458, eaat7108
DOI: 10.1126/scitranslmed.aat7108

Article Information

vol. 10 no. 458

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History: 
  • Received for publication April 25, 2018
  • Accepted for publication August 23, 2018
  • .

Author Information

  1. Lauren M. Byrne1,*,,
  2. Filipe B. Rodrigues1,,
  3. Eileanor B. Johnson1,
  4. Peter A. Wijeratne2,
  5. Enrico De Vita3,4,
  6. Daniel C. Alexander2,5,
  7. Giuseppe Palermo6,
  8. Christian Czech6,
  9. Scott Schobel6,
  10. Rachael I. Scahill1,
  11. Amanda Heslegrave7,
  12. Henrik Zetterberg7,8,9,10 and
  13. Edward J. Wild1,*
  1. 1Huntington’s Disease Centre, University College London (UCL) Institute of Neurology, London WC1N 3BG, UK.
  2. 2Centre for Medical Image Computing, Department of Computer Science, UCL, London WC1E 6EA, UK.
  3. 3Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK.
  4. 4Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.
  5. 5Clinical Imaging Research Centre, National University of Singapore, Singapore 117599, Singapore.
  6. 6Neuroscience, Ophthalmology, and Rare Diseases, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffman–La Roche Ltd., 4070 Basel, Switzerland.
  7. 7Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
  8. 8UK Dementia Research Institute at UCL, London WC1E 6BT, UK.
  9. 9Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, 405 30 Gothenburg, Sweden.
  10. 10Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, 413 45 Gothenburg, Sweden.
  1. *Corresponding author. Email: lauren.byrne.14{at}ucl.ac.uk (L.M.B.); e.wild{at}ucl.ac.uk (E.J.W.)
    • These authors contributed equally as first authors.

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