Contents
12 September 2018
Vol 10, Issue 458
Vol 10, Issue 458
Research Articles
- Thrombopoietin receptor–independent stimulation of hematopoietic stem cells by eltrombopag
Eltrombopag stimulates multilineage hematopoiesis through intracellular iron chelation.
- Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression
Leaky ryanodine receptor does not contribute to heart failure progression, but its normalization reduces arrhythmias and thereby improves survival in mice.
- Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington’s disease
Mutant huntingtin and neurofilament in biofluids may have prognostic potential in Huntington’s disease.
- ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone
ANP32A is a transcriptional regulator of ATM and provides protection against oxidative stress to prevent joint, brain, and bone disease.
Research Resource
- A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine
Bioinformatic analyses of human tissue samples were used to build a database of rhythmically expressed genes across the body.
Editors' Choice
- Network tools identify early signs of anxiety
Novel network analyses identify constellations of childhood symptoms that predict anxiety disorders and depression during adolescence and young adulthood.
- Breaking through the barrier: Finally hope for patients with cardiac amyloidosis
Tafamidis improves survival, reduces hospitalizations, and preserves quality of life and exercise tolerance for patients with cardiac amyloidosis.
- Graft-versus-host disease: Tread carefully on T cell suppression
CD28-targeting synergizes with mTOR inhibition to prevent graft-versus-host disease but increases infection-related fatality in nonhuman primates.
About The Cover
ONLINE COVER The Iron in the Fire of Hematopoiesis. This image shows molten iron, representing the focus of a study by Kao et al., where the authors linked the role of iron metabolism to unexpected benefits of a drug that bolsters platelets. Eltrombopag was designed as a thrombopoietin receptor agonist to stimulate platelet recovery for patients with thrombocytopenia, but clinical experience has shown that it also stimulates hematopoietic stem cell function in general, prompting a search for the underlying mechanism. The authors determined that in addition to its effects on the thrombopoietin receptor, eltrombopag chelates intracellular iron in hematopoietic stem cells, thus stimulating their activity. [CREDIT: THOMAS KOEHLER/PHOTOTHEK VIA GETTY IMAGES]
