Research ArticleLung Disease

Hypercapnia increases airway smooth muscle contractility via caspase-7–mediated miR-133a–RhoA signaling

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Science Translational Medicine  05 Sep 2018:
Vol. 10, Issue 457, eaat1662
DOI: 10.1126/scitranslmed.aat1662

Article Information

vol. 10 no. 457

PubMed: 
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History: 
  • Received for publication January 31, 2018
  • Resubmitted June 7, 2018
  • Accepted for publication August 16, 2018
  • .

Author Information

  1. Masahiko Shigemura1,2,
  2. Emilia Lecuona1,
  3. Martín Angulo3,
  4. Tetsuya Homma4,
  5. Diego A. Rodríguez5,
  6. Francisco J. Gonzalez-Gonzalez1,
  7. Lynn C. Welch1,
  8. Luciano Amarelle1,3,
  9. Seok-Jo Kim1,6,
  10. Naftali Kaminski7,
  11. G. R. Scott Budinger1,
  12. Julian Solway8 and
  13. Jacob I. Sznajder1,*
  1. 1Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA.
  2. 2First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
  3. 3Pathophysiology Department, School of Medicine, Universidad de la República, Montevideo, Uruguay.
  4. 4Division of Allergology and Respiratory Medicine, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
  5. 5Pulmonology Department, Hospital del Mar, Institut Hospital del Mar d’Investigacions Me`diques, Universitat Pompeu Fabra, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), ISCiii, Barcelona, Spain.
  6. 6Department of Medicine, Division of Pulmonary and Critical Care Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA.
  7. 7Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
  8. 8Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
  1. *Corresponding author. Email: j-sznajder{at}northwestern.edu

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