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Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus

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Science Translational Medicine  05 Sep 2018:
Vol. 10, Issue 457, eaao2966
DOI: 10.1126/scitranslmed.aao2966

Article Information

vol. 10 no. 457

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History: 
  • Received for publication July 5, 2017
  • Resubmitted April 11, 2018
  • Accepted for publication July 25, 2018
  • .

Author Information

  1. Emmanuel Clave1,2,*,
  2. Itauá Leston Araujo1,2,*,
  3. Cécile Alanio3,4,5,*,
  4. Etienne Patin6,7,8,*,
  5. Jacob Bergstedt9,*,
  6. Alejandra Urrutia3,4,5,10,
  7. Silvia Lopez-Lastra5,11,
  8. Yan Li5,11,
  9. Bruno Charbit3,
  10. Cameron Ross MacPherson3,
  11. Milena Hasan3,
  12. Breno Luiz Melo-Lima1,2,
  13. Corinne Douay1,2,
  14. Noémie Saut12,13,
  15. Marine Germain14,15,
  16. David-Alexandre Trégouët14,15,
  17. Pierre-Emmanuel Morange12,13,
  18. Magnus Fontes10,16,
  19. Darragh Duffy3,4,5,
  20. James P. Di Santo5,11,
  21. Lluis Quintana-Murci6,7,8,,
  22. Matthew L. Albert3,4,5,10,,,
  23. Antoine Toubert1,2,17,,
  24. The Milieu Intérieur Consortium§
  1. 1Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d’Hématologie, 75010 Paris, France.
  2. 2INSERM, UMRS-1160, Alloimmunity-Autoimmunity-Transplantation, 75010 Paris, France.
  3. 3Center for Translational Research, Technology Core, Institut Pasteur, 75015 Paris, France.
  4. 4Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, 75015 Paris, France.
  5. 5INSERM, UMRS-1223, 75015 Paris, France.
  6. 6Human Evolutionary Genetics, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France.
  7. 7CNRS UMR-2000, 75015 Paris, France.
  8. 8Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, 75015 Paris, France.
  9. 9Department of Automatic Control, Lund University, Lund SE-221, Sweden.
  10. 10Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.
  11. 11Innate Immunity Unit, Institut Pasteur, 75015 Paris, France.
  12. 12Laboratory of Haematology, La Timone Hospital, 13005 Marseille, France.
  13. 13Aix Marseille University, INSERM, UMRS-1260, INRA U1260, Center for Cardiovascular and Nutrition Research (C2VN), 13005 Marseille, France.
  14. 14Sorbonne Université, Université Paris 6/UPMC, INSERM, UMRS-1166, Genomics and Pathophysiology of Cardiovascular Diseases, 75013 Paris, France.
  15. 15Institute for Cardiometabolism and Nutrition, 75013 Paris, France.
  16. 16International Group for Data Analysis, Institut Pasteur, 75015 Paris, France.
  17. 17Laboratoire d’Immunologie et d’Histocompatibilité, Hôpital Saint-Louis, AP-HP, 75010 Paris, France.
  1. Corresponding author. Email: antoine.toubert{at}univ-paris-diderot.fr (A.T.); albert.matthew{at}gene.com (M.L.A.)
    • * These authors equally contributed to this work.

    • Co-coordinators of the Milieu Intérieur Consortium.

    • § A list of Milieu Intérieur Consortium authors appears at the end of Acknowledgments and in the Supplementary Materials.

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