Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus

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Science Translational Medicine  05 Sep 2018:
Vol. 10, Issue 457, eaao2966
DOI: 10.1126/scitranslmed.aao2966

Mining the Milieu Intérieur

Personalized medicine partly depends on understanding what causes variance even outside the context of overt disease. The Milieu Intérieur Consortium enrolled 1000 healthy adults to study how genetics and the environment influence the immune system. Clave et al. leveraged samples from this cohort to see how thymic output, known to decrease over time, is affected by other factors. In addition to seeing sex-dependent differences, a genome-wide association study revealed variants that were associated with thymic output, which was confirmed in an independent cohort and mouse models. The authors have also developed a Web application for other investigators to examine the Milieu Intérieur data.

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