05 September 2018
Vol 10, Issue 457

About The Cover

Cover image expansion

ONLINE COVER Unnerving Eosinophils. Shown here is a three-dimensional airway nerve model generated using biopsies from severe asthmatic patients. Drake et al. developed an imaging method to quantify nerve structure in healthy subjects and in patients with mild or severe asthma. Airway innervation was increased in patients with eosinophilic asthma and correlated with symptom severity. In a mouse model of bronchoconstriction, eosinophil depletion prevented nerve remodeling and reduced symptom severity. These results suggest that eosinophil-induced airway nerve remodeling contributes to disease severity in eosinophilic asthma. [CREDIT: DRAKE ET AL./SCIENCE TRANSLATIONAL MEDICINE]