Contents
05 September 2018
Vol 10, Issue 457
Vol 10, Issue 457
Research Articles
- Eosinophils increase airway sensory nerve density in mice and in human asthma
Eosinophils increase airway sensory nerve density in humans with asthma and in mice, which promotes airway hyperresponsiveness.
- Hypercapnia increases airway smooth muscle contractility via caspase-7–mediated miR-133a–RhoA signaling
Elevated carbon dioxide (hypercapnia) activates complex signaling pathways in airway smooth muscle cells, resulting in airway constriction.
- Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus
Aging, sex, and genetics substantially affect human thymic function.
Research Resource
- A machine learning approach for somatic mutation discovery
A machine learning approach to detect somatic mutations in cancer patients outperforms existing methods and may improve clinical outcome.
Editors' Choice
- Cutting choline conversion in commensals to treat cardiovascular disease
A strategy to selectively target a microbial enzyme reduces the production of a metabolite linked to the development of cardiovascular disease.
- Special delivery by “armored” CAR-T
The integration of immune checkpoint blockade with CAR-T cell therapy improves antitumor efficacy with potential for reduced side effects.
- Epilepsy surgery: Think globally, act locally
A computational approach predicts the success of epilepsy surgery based upon presurgical structural connectivity.
About The Cover
ONLINE COVER Unnerving Eosinophils. Shown here is a three-dimensional airway nerve model generated using biopsies from severe asthmatic patients. Drake et al. developed an imaging method to quantify nerve structure in healthy subjects and in patients with mild or severe asthma. Airway innervation was increased in patients with eosinophilic asthma and correlated with symptom severity. In a mouse model of bronchoconstriction, eosinophil depletion prevented nerve remodeling and reduced symptom severity. These results suggest that eosinophil-induced airway nerve remodeling contributes to disease severity in eosinophilic asthma. [CREDIT: DRAKE ET AL./SCIENCE TRANSLATIONAL MEDICINE]