Research ArticlePain
A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates
- Huiping Ding1,*,
- Norikazu Kiguchi1,2,*,
- Dennis Yasuda3,
- Pankaj R. Daga3,
- Willma E. Polgar3,
- James J. Lu3,
- Paul W. Czoty1,
- Shiroh Kishioka2,
- Nurulain T. Zaveri3,† and
- Mei-Chuan Ko1,4,†
- 1Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
- 2Department of Pharmacology, Wakayama Medical University, Wakayama, Japan.
- 3Astraea Therapeutics, Mountain View, CA 94043, USA.
- 4W.G. Hefner Veterans Affairs Medical Center, Salisbury, NC 28144, USA.
- ↵†Corresponding author. Email: nurulain{at}astraeatherapeutics.com (N.T.Z.); mko{at}wakehealth.edu (M.-C.K.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 29 Aug 2018:
Vol. 10, Issue 456, eaar3483
DOI: 10.1126/scitranslmed.aar3483
Vol. 10, Issue 456, eaar3483
DOI: 10.1126/scitranslmed.aar3483
Huiping Ding
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Norikazu Kiguchi
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.Department of Pharmacology, Wakayama Medical University, Wakayama, Japan.
Dennis Yasuda
Astraea Therapeutics, Mountain View, CA 94043, USA.
Pankaj R. Daga
Astraea Therapeutics, Mountain View, CA 94043, USA.
Willma E. Polgar
Astraea Therapeutics, Mountain View, CA 94043, USA.
James J. Lu
Astraea Therapeutics, Mountain View, CA 94043, USA.
Paul W. Czoty
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Shiroh Kishioka
Department of Pharmacology, Wakayama Medical University, Wakayama, Japan.
Nurulain T. Zaveri
Astraea Therapeutics, Mountain View, CA 94043, USA.
Mei-Chuan Ko
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.W.G. Hefner Veterans Affairs Medical Center, Salisbury, NC 28144, USA.
