Research ArticlePain
A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates
- Huiping Ding1,*,
- Norikazu Kiguchi1,2,*,
- Dennis Yasuda3,
- Pankaj R. Daga3,
- Willma E. Polgar3,
- James J. Lu3,
- Paul W. Czoty1,
- Shiroh Kishioka2,
- Nurulain T. Zaveri3,† and
- Mei-Chuan Ko1,4,†
- 1Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
- 2Department of Pharmacology, Wakayama Medical University, Wakayama, Japan.
- 3Astraea Therapeutics, Mountain View, CA 94043, USA.
- 4W.G. Hefner Veterans Affairs Medical Center, Salisbury, NC 28144, USA.
- ↵†Corresponding author. Email: nurulain{at}astraeatherapeutics.com (N.T.Z.); mko{at}wakehealth.edu (M.-C.K.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 29 Aug 2018:
Vol. 10, Issue 456, eaar3483
DOI: 10.1126/scitranslmed.aar3483
Vol. 10, Issue 456, eaar3483
DOI: 10.1126/scitranslmed.aar3483
Huiping Ding
1Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Norikazu Kiguchi
1Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
2Department of Pharmacology, Wakayama Medical University, Wakayama, Japan.
Dennis Yasuda
3Astraea Therapeutics, Mountain View, CA 94043, USA.
Pankaj R. Daga
3Astraea Therapeutics, Mountain View, CA 94043, USA.
Willma E. Polgar
3Astraea Therapeutics, Mountain View, CA 94043, USA.
James J. Lu
3Astraea Therapeutics, Mountain View, CA 94043, USA.
Paul W. Czoty
1Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Shiroh Kishioka
2Department of Pharmacology, Wakayama Medical University, Wakayama, Japan.
Nurulain T. Zaveri
3Astraea Therapeutics, Mountain View, CA 94043, USA.
Mei-Chuan Ko
1Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
4W.G. Hefner Veterans Affairs Medical Center, Salisbury, NC 28144, USA.
