Research ArticlePain

A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

See allHide authors and affiliations

Science Translational Medicine  29 Aug 2018:
Vol. 10, Issue 456, eaar3483
DOI: 10.1126/scitranslmed.aar3483

Article Information

vol. 10 no. 456

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 30, 2017
  • Resubmitted February 7, 2018
  • Accepted for publication August 9, 2018

Author Information

  1. Huiping Ding1,*,
  2. Norikazu Kiguchi1,2,*,
  3. Dennis Yasuda3,
  4. Pankaj R. Daga3,
  5. Willma E. Polgar3,
  6. James J. Lu3,
  7. Paul W. Czoty1,
  8. Shiroh Kishioka2,
  9. Nurulain T. Zaveri3, and
  10. Mei-Chuan Ko1,4,
  1. 1Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
  2. 2Department of Pharmacology, Wakayama Medical University, Wakayama, Japan.
  3. 3Astraea Therapeutics, Mountain View, CA 94043, USA.
  4. 4W.G. Hefner Veterans Affairs Medical Center, Salisbury, NC 28144, USA.
  1. Corresponding author. Email: nurulain{at}astraeatherapeutics.com (N.T.Z.); mko{at}wakehealth.edu (M.-C.K.)
    • * These authors contributed equally to this work.

    Altmetric

    Article usage

    Article usage: August 2018 to April 2019

    AbstractFullPdf
    Aug 20180140661914
    Sep 20183414150422892
    Oct 20187534392206
    Nov 20182638267184
    Dec 20181452136137
    Jan 201988210698
    Feb 20196758763
    Mar 20197529981
    Apr 201950111448