29 August 2018
Vol 10, Issue 456

About The Cover

Cover image expansion

ONLINE COVER MORe NOR for Pain Relief. Opioids selectively targeting the mu opioid receptor (MOR) are the most effective treatment for pain. However, their use is limited by severe side effects such as respiratory depression, tolerance, dependence and risk of abuse. A new study (Ding et al.) shows that simultaneous activation of MOR and nociceptin opioid receptor (NOR) with a single molecule called AT-121 induced pain relief without side effects in nonhuman primates. The results indicate that a small molecule agonist that targets both MOR and NOR might be a safe and effective strategy for treating pain. [CREDIT: MEDIA FOR MEDICAL/UIG VIA GETTY IMAGES]