Research ArticleAsthma
An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness
- View ORCID ProfileDhiren F. Patel1,
- Teresa Peiró1,2,
- Amelia Shoemark3,
- Samia Akthar1,
- Simone A. Walker1,
- View ORCID ProfileAleksander M. Grabiec4,5,
- Patricia L. Jackson6,7,
- Tracy Hussell4,
- Amit Gaggar6,7,
- Xin Xu6,7,
- View ORCID ProfileJennifer L. Trevor6,7,
- Jindong Li6,7,
- Chad Steele6,
- View ORCID ProfileGael Tavernier8,9,
- View ORCID ProfileJ. Edwin Blalock6,
- View ORCID ProfileRobert M. Niven8,9,
- Lisa G. Gregory1,
- Angela Simpson8,9,
- View ORCID ProfileClare M. Lloyd1 and
- View ORCID ProfileRobert J. Snelgrove1,*
- 1Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
- 2Departamento de Ciencias Biomédicas, Universidad Cardenal Herrera–CEU, CEU Universities, Valencia 46115, Spain.
- 3Royal Brompton and Harefield National Health Service (NHS) Trust, London SW3 6NP, UK.
- 4Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester M13 9NT, UK.
- 5Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków 30-387, Poland.
- 6Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- 7Birmingham VA Medical Center, Birmingham, AL 35233, USA.
- 8Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
- 9Manchester University NHS Foundation Trust, Manchester M23 9LT, UK.
- ↵*Corresponding author. Email: robert.snelgrove{at}imperial.ac.uk
See allHide authors and affiliations
Science Translational Medicine 22 Aug 2018:
Vol. 10, Issue 455, eaaq0693
DOI: 10.1126/scitranslmed.aaq0693
Vol. 10, Issue 455, eaaq0693
DOI: 10.1126/scitranslmed.aaq0693
Dhiren F. Patel
1Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Teresa Peiró
1Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
2Departamento de Ciencias Biomédicas, Universidad Cardenal Herrera–CEU, CEU Universities, Valencia 46115, Spain.
Amelia Shoemark
3Royal Brompton and Harefield National Health Service (NHS) Trust, London SW3 6NP, UK.
Samia Akthar
1Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Simone A. Walker
1Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Aleksander M. Grabiec
4Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester M13 9NT, UK.
5Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków 30-387, Poland.
Patricia L. Jackson
6Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
7Birmingham VA Medical Center, Birmingham, AL 35233, USA.
Tracy Hussell
4Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester M13 9NT, UK.
Amit Gaggar
6Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
7Birmingham VA Medical Center, Birmingham, AL 35233, USA.
Xin Xu
6Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
7Birmingham VA Medical Center, Birmingham, AL 35233, USA.
Jennifer L. Trevor
6Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
7Birmingham VA Medical Center, Birmingham, AL 35233, USA.
Jindong Li
6Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
7Birmingham VA Medical Center, Birmingham, AL 35233, USA.
Chad Steele
6Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Gael Tavernier
8Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
9Manchester University NHS Foundation Trust, Manchester M23 9LT, UK.
J. Edwin Blalock
6Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Robert M. Niven
8Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
9Manchester University NHS Foundation Trust, Manchester M23 9LT, UK.
Lisa G. Gregory
1Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Angela Simpson
8Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
9Manchester University NHS Foundation Trust, Manchester M23 9LT, UK.
Clare M. Lloyd
1Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Robert J. Snelgrove
1Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
