Research ArticleAsthma

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness

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Science Translational Medicine  22 Aug 2018:
Vol. 10, Issue 455, eaaq0693
DOI: 10.1126/scitranslmed.aaq0693

Extracellular matrix extends its influence in asthma

The interplay between immune cells and smooth muscle cells in asthma pathogenesis and response to treatment is under increasing scrutiny. Patel et al. focused on how leukotrienes can modulate immune inflammation and airway hypersensitivity. Mice lacking leukotriene A4 hydrolase had exaggerated epithelial remodeling but dampened immune responses in a house dust mite model of asthma. This was due to release of Pro-Gly-Pro (PGP), a component of the extracellular matrix, which was also elevated in the sputum from severe asthmatics in two clinical cohorts. Their results showcase how the extracellular matrix is a dynamic player in disease and reveal a mediator to be targeted in asthma therapy.

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