Research ArticleObesity
Cleavage of the leptin receptor by matrix metalloproteinase–2 promotes leptin resistance and obesity in mice
- Rafi Mazor1,*,†,
- Dinorah Friedmann-Morvinski2,3,4,*,†,
- Tom Alsaigh1,
- Oded Kleifeld5,
- Erik B. Kistler1,6,7,
- Liat Rousso-Noori3,4,
- Cheng Huang5,
- Joyce B. Li1,
- Inder M. Verma2 and
- Geert W. Schmid-Schönbein1
- 1Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
- 2Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
- 3Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
- 4Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel.
- 5Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
- 6Veterans Affairs San Diego Healthcare System, San Diego, CA 92093, USA.
- 7Department of Anesthesiology and Critical Care, University of California, San Diego, La Jolla, CA 92093, USA.
- ↵†Corresponding author. Email: rmazor{at}ucsd.edu (R.M.); dino{at}post.tau.ac.il (D.F.-M.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 22 Aug 2018:
Vol. 10, Issue 455, eaah6324
DOI: 10.1126/scitranslmed.aah6324
Vol. 10, Issue 455, eaah6324
DOI: 10.1126/scitranslmed.aah6324
Rafi Mazor
1Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Dinorah Friedmann-Morvinski
2Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
3Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
4Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel.
Tom Alsaigh
1Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Oded Kleifeld
5Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
Erik B. Kistler
1Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
6Veterans Affairs San Diego Healthcare System, San Diego, CA 92093, USA.
7Department of Anesthesiology and Critical Care, University of California, San Diego, La Jolla, CA 92093, USA.
Liat Rousso-Noori
3Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
4Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel.
Cheng Huang
5Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
Joyce B. Li
1Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Inder M. Verma
2Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Geert W. Schmid-Schönbein
1Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
