Research ArticleObesity
Cleavage of the leptin receptor by matrix metalloproteinase–2 promotes leptin resistance and obesity in mice
- Rafi Mazor1,*,†,
- Dinorah Friedmann-Morvinski2,3,4,*,†,
- Tom Alsaigh1,
- Oded Kleifeld5,
- Erik B. Kistler1,6,7,
- Liat Rousso-Noori3,4,
- Cheng Huang5,
- Joyce B. Li1,
- Inder M. Verma2 and
- Geert W. Schmid-Schönbein1
- 1Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
- 2Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
- 3Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
- 4Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel.
- 5Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
- 6Veterans Affairs San Diego Healthcare System, San Diego, CA 92093, USA.
- 7Department of Anesthesiology and Critical Care, University of California, San Diego, La Jolla, CA 92093, USA.
- ↵†Corresponding author. Email: rmazor{at}ucsd.edu (R.M.); dino{at}post.tau.ac.il (D.F.-M.)
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Science Translational Medicine 22 Aug 2018:
Vol. 10, Issue 455, eaah6324
DOI: 10.1126/scitranslmed.aah6324
