Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth

Kun Xuan; Bei Li; Hao Guo; Wei Sun; Xiaoxing Kou; Xiaoning He; Yongjie Zhang; Jin Sun; Anqi Liu; Li Liao; Shiyu Liu; Wenjia Liu; Chenghu Hu; Songtao Shi; Yan Jin

doi:10.1126/scitranslmed.aaf3227

Research ArticleStem Cells

Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth

Kun Xuan¹,²,*,
Bei Li¹,*,
Hao Guo¹,²,*,
Wei Sun³,*,
Xiaoxing Kou⁴,
Xiaoning He¹,
Yongjie Zhang¹,
Jin Sun¹,
Anqi Liu¹,²,
Li Liao¹,
Shiyu Liu¹,
Wenjia Liu¹,
Chenghu Hu¹,
Songtao Shi⁴,† and
Yan Jin¹,†

¹MS-State Key Laboratory, School of Stomatology, Fourth Military Medical University, Xi’an, China.
²Department of Pediatric Dentistry, School of Stomatology, Fourth Military Medical University, Xi’an, China.
³Institute for Biomedical Sciences of Pain, Tangdu Hospital, Fourth Military Medical University, Xi’an, China.
⁴Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.

↵†Corresponding author. Email: yanjin{at}fmmu.edu.cn (Y.J.); songtaos{at}upenn.edu (S.S.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 22 Aug 2018:
Vol. 10, Issue 455, eaaf3227
DOI: 10.1126/scitranslmed.aaf3227

Kun Xuan

MS-State Key Laboratory, School of Stomatology, Fourth Military Medical University, Xi’an, China.Department of Pediatric Dentistry, School of Stomatology, Fourth Military Medical University, Xi’an, China.

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Bei Li

MS-State Key Laboratory, School of Stomatology, Fourth Military Medical University, Xi’an, China.

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Hao Guo

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Wei Sun

Institute for Biomedical Sciences of Pain, Tangdu Hospital, Fourth Military Medical University, Xi’an, China.

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Xiaoxing Kou

Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.

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Xiaoning He

MS-State Key Laboratory, School of Stomatology, Fourth Military Medical University, Xi’an, China.

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Yongjie Zhang

MS-State Key Laboratory, School of Stomatology, Fourth Military Medical University, Xi’an, China.

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Jin Sun

MS-State Key Laboratory, School of Stomatology, Fourth Military Medical University, Xi’an, China.

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Anqi Liu

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Li Liao

MS-State Key Laboratory, School of Stomatology, Fourth Military Medical University, Xi’an, China.

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Shiyu Liu

MS-State Key Laboratory, School of Stomatology, Fourth Military Medical University, Xi’an, China.

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Wenjia Liu

MS-State Key Laboratory, School of Stomatology, Fourth Military Medical University, Xi’an, China.

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Chenghu Hu

MS-State Key Laboratory, School of Stomatology, Fourth Military Medical University, Xi’an, China.

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Songtao Shi

Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.

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For correspondence: yanjin@fmmu.edu.cn songtaos@upenn.edu

Yan Jin

MS-State Key Laboratory, School of Stomatology, Fourth Military Medical University, Xi’an, China.

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For correspondence: yanjin@fmmu.edu.cn songtaos@upenn.edu

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Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth

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