Research ArticleStem Cells

Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth

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Science Translational Medicine  22 Aug 2018:
Vol. 10, Issue 455, eaaf3227
DOI: 10.1126/scitranslmed.aaf3227

Tooth stem cells regenerate smiles

Dental pulp necrosis is one of the most common pathological conditions that results in tooth loss. However, regeneration of functional dental pulp has proved difficult. In a new study, Xuan et al. implanted ex vivo expanded autologous tooth stem cells from deciduous teeth in two animal models and in human patients. They demonstrated regeneration of dental pulp containing an odontoblast layer, blood vessels, and nerves in the implanted teeth and rescue of sensation to stimuli such as temperature. This work suggests that implantation of tooth stem cells can provide partial recovery of teeth injured by trauma.

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