Tooth stem cells regenerate smiles
Dental pulp necrosis is one of the most common pathological conditions that results in tooth loss. However, regeneration of functional dental pulp has proved difficult. In a new study, Xuan et al. implanted ex vivo expanded autologous tooth stem cells from deciduous teeth in two animal models and in human patients. They demonstrated regeneration of dental pulp containing an odontoblast layer, blood vessels, and nerves in the implanted teeth and rescue of sensation to stimuli such as temperature. This work suggests that implantation of tooth stem cells can provide partial recovery of teeth injured by trauma.
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