22 August 2018
Vol 10, Issue 455

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ONLINE COVER Overcoming Resistance to Getting Lean. Some individuals with obesity have leptin resistance whereby the satiety hormone leptin does not signal appropriately to the brain, resulting in a failure to halt food intake. Leptin resistance leads to overeating and difficulty losing weight. Now, Mazor et al. show that the matrix metalloproteinase-2 (Mmp-2) enzyme is overexpressed in obese mice and mediates leptin resistance by promoting degradation of the leptin receptor. Mice lacking Mmp-2 fed a high fat diet showed reduced weight gain compared to wild-type animals. This suggests that MMP-2 might be an effective target for developing drugs to treat obesity. [CREDIT: TURK_STOCK_PHOTOGRAPHER/ISTOCK.COM]