A protective Langerhans cell–keratinocyte axis that is dysfunctional in photosensitivity

William D. Shipman; Susan Chyou; Anusha Ramanathan; Peter M. Izmirly; Sneh Sharma; Tania Pannellini; Dragos C. Dasoveanu; Xiaoping Qing; Cynthia M. Magro; Richard D. Granstein; Michelle A. Lowes; Eric G. Pamer; Daniel H. Kaplan; Jane E. Salmon; Babak J. Mehrara; James W. Young; Robert M. Clancy; Carl P. Blobel; Theresa T. Lu

doi:10.1126/scitranslmed.aap9527

Research ArticleSKIN

A protective Langerhans cell–keratinocyte axis that is dysfunctional in photosensitivity

William D. Shipman ¹,²,³,
Susan Chyou³,
Anusha Ramanathan³,
Peter M. Izmirly⁴,
Sneh Sharma⁵,⁶,
Tania Pannellini³,
Dragos C. Dasoveanu³,⁷,
Xiaoping Qing³,
Cynthia M. Magro⁸,
Richard D. Granstein⁹,
Michelle A. Lowes¹⁰,
Eric G. Pamer⁶,
Daniel H. Kaplan¹¹,¹²,
Jane E. Salmon²,³,¹³,¹⁴,
Babak J. Mehrara¹⁵,
James W. Young⁵,⁶,¹⁰,¹³,¹⁶,
Robert M. Clancy⁴,
Carl P. Blobel⁷,¹³,¹⁷,¹⁸ and
Theresa T. Lu ²,³,¹⁴,¹⁹,*

¹Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY 10065, USA.
²Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
³Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA.
⁴Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.
⁵Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
⁶Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
⁷Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY 10065, USA.
⁸Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
⁹Department of Dermatology, Weill Cornell Medicine, New York, NY 10065, USA.
¹⁰Rockefeller University, New York, NY 10065, USA.
¹¹Department of Dermatology, University of Pittsburgh, PA 15260, USA.
¹²Department of Immunology, University of Pittsburgh, PA 15260, USA.
¹³Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
¹⁴Division of Rheumatology and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA.
¹⁵Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
¹⁶Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
¹⁷Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.
¹⁸Institute for Advanced Studies, Technical University Munich, Munich, Germany.
¹⁹Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA.

↵*Corresponding author. Email: lut{at}hss.edu

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Science Translational Medicine 15 Aug 2018:
Vol. 10, Issue 454, eaap9527
DOI: 10.1126/scitranslmed.aap9527

William D. Shipman

Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY 10065, USA.Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA.

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Susan Chyou

Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA.

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Anusha Ramanathan

Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA.

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Peter M. Izmirly

Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.

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Sneh Sharma

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Tania Pannellini

Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA.

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Dragos C. Dasoveanu

Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA.Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY 10065, USA.

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Xiaoping Qing

Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA.

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Cynthia M. Magro

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.

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Richard D. Granstein

Department of Dermatology, Weill Cornell Medicine, New York, NY 10065, USA.

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Michelle A. Lowes

Rockefeller University, New York, NY 10065, USA.

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Eric G. Pamer

Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Daniel H. Kaplan

Department of Dermatology, University of Pittsburgh, PA 15260, USA.Department of Immunology, University of Pittsburgh, PA 15260, USA.

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Jane E. Salmon

Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA.Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.Division of Rheumatology and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA.

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Babak J. Mehrara

Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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James W. Young

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.Rockefeller University, New York, NY 10065, USA.Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Robert M. Clancy

Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.

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Carl P. Blobel

Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY 10065, USA.Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.Institute for Advanced Studies, Technical University Munich, Munich, Germany.

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Theresa T. Lu

Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA.Division of Rheumatology and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA.Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA.

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For correspondence: lut@hss.edu

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Langerhans cells limit ultraviolet radiation–induced keratinocyte apoptosis and skin injury, and this axis is dysfunctional in lupus photosensitivity.

A protective Langerhans cell–keratinocyte axis that is dysfunctional in photosensitivity

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