Research ArticleLiver disease

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

See allHide authors and affiliations

Science Translational Medicine  15 Aug 2018:
Vol. 10, Issue 454, eaan1230
DOI: 10.1126/scitranslmed.aan1230

Article Information

vol. 10 no. 454

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 7, 2017
  • Resubmitted October 4, 2017
  • Accepted for publication March 13, 2018

Author Information

  1. Thomas G. Bird1,2,3,*,
  2. Miryam Müller1,
  3. Luke Boulter2,4,
  4. David F. Vincent1,
  5. Rachel A. Ridgway1,
  6. Elena Lopez-Guadamillas5,
  7. Wei-Yu Lu2,
  8. Thomas Jamieson1,
  9. Olivier Govaere6,
  10. Andrew D. Campbell1,
  11. Sofía Ferreira-Gonzalez2,
  12. Alicia M. Cole1,
  13. Trevor Hay7,
  14. Kenneth J. Simpson2,
  15. William Clark1,
  16. Ann Hedley1,
  17. Mairi Clarke8,
  18. Pauline Gentaz1,
  19. Colin Nixon1,
  20. Steven Bryce1,
  21. Christos Kiourtis1,9,
  22. Joep Sprangers1,
  23. Robert J. B. Nibbs8,
  24. Nico Van Rooijen10,
  25. Laurent Bartholin11,
  26. Steven R. McGreal12,
  27. Udayan Apte12,
  28. Simon T. Barry13,
  29. John P. Iredale3,14,
  30. Alan R. Clarke7,,
  31. Manuel Serrano5,15,
  32. Tania A. Roskams6,
  33. Owen J. Sansom1,9 and
  34. Stuart J. Forbes2,3
  1. 1Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  2. 2Medical Research Council (MRC) Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
  3. 3MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh EH164TJ, UK.
  4. 4MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh EH4 2XU, UK.
  5. 5Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
  6. 6Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven, B-3000 Leuven, Belgium.
  7. 7School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.
  8. 8Institute for Infection Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
  9. 9Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.
  10. 10Vrije Universiteit Medical Center, Department of Molecular Cell Biology, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands.
  11. 11Centre de Recherche en Cancérologie de Lyon, UMR INSERM 1052, CNRS 5286, Lyon I University UMR S 1052, 69373 Lyon Cedex 08, France.
  12. 12Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.
  13. 13Oncology, IMED Biotech Unit, AstraZeneca, Cambridge CB2 0AA, UK.
  14. 14University of Bristol, Senate House, Tyndall Avenue, Bristol BS8 1TH, UK.
  15. 15Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, and Catalan Institution for Research and Advanced Studies, Barcelona, Spain.
  1. *Corresponding author. Email: t.bird{at}beatson.gla.ac.uk
  • Author deceased.

Altmetric

Article usage

Article usage: August 2018 to July 2019

AbstractFullPdf
Aug 201899971648907
Sep 2018782303283
Oct 2018585178132
Nov 20181094107122
Dec 2018888104103
Jan 2019308106100
Feb 20192326976
Mar 20191836872
Apr 20191446053
May 20191356559
Jun 20191215139
Jul 2019732528