PerspectiveParkinson’s Disease

Finding useful biomarkers for Parkinson’s disease

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Science Translational Medicine  15 Aug 2018:
Vol. 10, Issue 454, eaam6003
DOI: 10.1126/scitranslmed.aam6003

Article Information

vol. 10 no. 454

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 15, 2016
  • Accepted for publication December 14, 2017
  • .

Author Information

  1. Alice S. Chen-Plotkin1,*,
  2. Roger Albin2,3,
  3. Roy Alcalay4,
  4. Debra Babcock5,
  5. Vikram Bajaj6,
  6. Dubois Bowman7,
  7. Alex Buko8,
  8. Jesse Cedarbaum9,
  9. Daniel Chelsky10,
  10. Mark R. Cookson11,
  11. Ted M. Dawson12,
  12. Richard Dewey13,
  13. Tatiana Foroud14,
  14. Mark Frasier15,
  15. Dwight German16,
  16. Katrina Gwinn5,
  17. Xuemei Huang17,
  18. Catherine Kopil15,
  19. Thomas Kremer18,
  20. Shirley Lasch19,
  21. Ken Marek19,
  22. Jarrod A. Marto20,21,22,
  23. Kalpana Merchant23,
  24. Brit Mollenhauer24,25,
  25. Anna Naito15,
  26. Judith Potashkin26,
  27. Alyssa Reimer15,
  28. Liana S. Rosenthal27,
  29. Rachel Saunders-Pullman28,
  30. Clemens R. Scherzer29,
  31. Todd Sherer15,
  32. Andrew Singleton30,
  33. Margaret Sutherland5,
  34. Ines Thiele31,
  35. Marcel van der Brug32,
  36. Kendall Van Keuren-Jensen33,
  37. David Vaillancourt34,
  38. David Walt22,
  39. Andrew West35 and
  40. Jing Zhang36
  1. 1Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  2. 2Neurology Service and GRECC, VAAHS, Ann Arbor, MI 48105, USA.
  3. 3Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
  4. 4Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
  5. 5National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.
  6. 6Verily/Google Life Sciences, South San Francisco, CA 94080, USA.
  7. 7Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
  8. 8Human Metabolome Technology–America, Boston, MA 02134, USA.
  9. 9Biogen, Cambridge, MA 02142, USA.
  10. 10Caprion Biosciences, Montreal, Quebec H2X 3Y7, Canada.
  11. 11Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, MD 20892, USA.
  12. 12Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  13. 13Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  14. 14Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  15. 15The Michael J. Fox Foundation for Parkinson’s Research, New York, NY 10163, USA.
  16. 16Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  17. 17Department of Neurology, Penn State University–Hershey Medical Center, Hershey, PA 17033, USA.
  18. 18Pharmaceutical Research and Early Development, NORD Discovery and Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.
  19. 19Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA.
  20. 20Departments of Cancer Biology and Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
  21. 21Blais Proteomics Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
  22. 22Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA.
  23. 23Chaperone Therapeutics, Portland, OR 97229, USA.
  24. 24Paracelsus-Elena-Klinik, 34128 Kassel, Germany.
  25. 25University Medical Center, 37075 Goettingen, Germany.
  26. 26Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Chicago, IL 60064, USA.
  27. 27Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  28. 28Department of Neurology, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, New York, NY 10003, USA.
  29. 29Center for Advanced Parkinson’s Disease Research and Precision Neurology Program, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  30. 30Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
  31. 31Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg.
  32. 32Genentech, San Francisco, CA 94080, USA.
  33. 33Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
  34. 34Department of Applied Physiology, Biomedical Engineering, and Neurology, University of Florida, Gainesville, FL 32611, USA.
  35. 35Department of Neurology, University of Alabama, Birmingham, AL 35233, USA.
  36. 36Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  1. *Corresponding author. Email: chenplot{at}pennmedicine.upenn.edu

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