15 August 2018
Vol 10, Issue 454
  • Perspective

    • Finding useful biomarkers for Parkinson’s disease

      The recent advent of an “ecosystem” of shared biosample biorepositories and data sets will aid efforts to define biomarkers for Parkinson’s disease.

  • Research Articles

  • Editors' Choice

About The Cover

Cover image expansion

ONLINE COVER Tracking Malevolent Mycobacteria. Tuberculosis, caused by the bacterium Mycobacterium tuberculosis (pictured here), is a potentially fatal lung infection that is difficult to diagnose. Cheng et al. developed a fluorescent probe to label live M. tuberculosis. The probe rapidly fluoresced upon activation by an enzyme within the bacteria and remained tethered in place within the cell. The probe could distinguish live bacteria from dead bacteria, labeled patient sputum samples, and showed specificity for mycobacteria over other types of bacteria. The authors also developed a microfluidic chip and automated imaging-based counting method to quantify live bacteria. In addition to rapid tuberculosis diagnosis, this probe and chip could be useful for drug testing. [CREDIT: KATERYNA KON/SCIENCE SOURCE]