Contents
15 August 2018
Vol 10, Issue 454
Vol 10, Issue 454
Perspective
- Finding useful biomarkers for Parkinson’s disease
The recent advent of an “ecosystem” of shared biosample biorepositories and data sets will aid efforts to define biomarkers for Parkinson’s disease.
Research Articles
- Rapid and specific labeling of single live Mycobacterium tuberculosis with a dual-targeting fluorogenic probe
A dual-targeted fluorogenic probe and microfluidic chip enables single-cell labeling and quantification of live Mycobacterium tuberculosis.
- A protective Langerhans cell–keratinocyte axis that is dysfunctional in photosensitivity
Langerhans cells limit ultraviolet radiation–induced keratinocyte apoptosis and skin injury, and this axis is dysfunctional in lupus photosensitivity.
- KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice
Modulation of energy metabolism with the small-molecule KHS101 promoted tumor-selective death of human glioblastoma cells and reduced tumor growth in mice.
- TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence
Inhibiting acute injury–induced senescence mediated by TGFβ signaling in regenerative epithelium improves liver regeneration.
Editors' Choice
- The resistance potential of a quintessential commensal
Whole-genome sequencing and microbiome analysis illuminate the emergence of invasive, linezolid-resistant Staphylococcus epidermidis.
- Platelets prefer to be shaken, not stirred
Turbulent-flow bioreactors enable clinical scale production of mature, functional platelets.
- Designer platelets pump up PD-1 blockade
Genetically engineered platelets promote eradication of residual tumor by immune cells after surgery in mice.
About The Cover
ONLINE COVER Tracking Malevolent Mycobacteria. Tuberculosis, caused by the bacterium Mycobacterium tuberculosis (pictured here), is a potentially fatal lung infection that is difficult to diagnose. Cheng et al. developed a fluorescent probe to label live M. tuberculosis. The probe rapidly fluoresced upon activation by an enzyme within the bacteria and remained tethered in place within the cell. The probe could distinguish live bacteria from dead bacteria, labeled patient sputum samples, and showed specificity for mycobacteria over other types of bacteria. The authors also developed a microfluidic chip and automated imaging-based counting method to quantify live bacteria. In addition to rapid tuberculosis diagnosis, this probe and chip could be useful for drug testing. [CREDIT: KATERYNA KON/SCIENCE SOURCE]