Research ArticleCancer
Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP)
- Masturah Bte Mohd Abdul Rashid1,2,
- Tan Boon Toh1,
- Lissa Hooi1,
- Aleidy Silva3,
- Yanzhou Zhang1,
- Pei Fang Tan4,
- Ai Ling Teh4,
- Neerja Karnani4,5,
- Sudhakar Jha1,5,
- Chih-Ming Ho3,6,7,
- Wee Joo Chng1,8,
- Dean Ho2,6,7,9,10,11 and
- Edward Kai-Hua Chow1,2,*
- 1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
- 2Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
- 3Department of Mechanical Engineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
- 4Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.
- 5Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
- 6Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
- 7Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
- 8Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119228, Singapore.
- 9Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.
- 10Bioengineering Institute for Global Health Research and Technology, National University of Singapore, Singapore 117599, Singapore.
- 11Division of Oral Biology and Medicine and the Jane and Jerry Weintraub Center for Reconstructive Biotechnology, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
- ↵*Corresponding author. Email: csikce{at}nus.edu.sg
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Science Translational Medicine 08 Aug 2018:
Vol. 10, Issue 453, eaan0941
DOI: 10.1126/scitranslmed.aan0941
Vol. 10, Issue 453, eaan0941
DOI: 10.1126/scitranslmed.aan0941
Masturah Bte Mohd Abdul Rashid
Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Tan Boon Toh
Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Lissa Hooi
Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Aleidy Silva
Department of Mechanical Engineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yanzhou Zhang
Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Pei Fang Tan
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.
Ai Ling Teh
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.
Neerja Karnani
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Sudhakar Jha
Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Chih-Ming Ho
Department of Mechanical Engineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Wee Joo Chng
Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119228, Singapore.
Dean Ho
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.Bioengineering Institute for Global Health Research and Technology, National University of Singapore, Singapore 117599, Singapore.Division of Oral Biology and Medicine and the Jane and Jerry Weintraub Center for Reconstructive Biotechnology, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Edward Kai-Hua Chow
Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
