Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP)

Masturah Bte Mohd Abdul Rashid; Tan Boon Toh; Lissa Hooi; Aleidy Silva; Yanzhou Zhang; Pei Fang Tan; Ai Ling Teh; Neerja Karnani; Sudhakar Jha; Chih-Ming Ho; Wee Joo Chng; Dean Ho; Edward Kai-Hua Chow

doi:10.1126/scitranslmed.aan0941

Research ArticleCancer

Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP)

Masturah Bte Mohd Abdul Rashid¹,²,
Tan Boon Toh¹,
Lissa Hooi¹,
Aleidy Silva³,
Yanzhou Zhang¹,
Pei Fang Tan⁴,
Ai Ling Teh⁴,
Neerja Karnani⁴,⁵,
Sudhakar Jha ¹,⁵,
Chih-Ming Ho³,⁶,⁷,
Wee Joo Chng ¹,⁸,
Dean Ho ²,⁶,⁷,⁹,¹⁰,¹¹ and
Edward Kai-Hua Chow ¹,²,*

¹Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
²Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
³Department of Mechanical Engineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
⁴Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.
⁵Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
⁶Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
⁷Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
⁸Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119228, Singapore.
⁹Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.
¹⁰Bioengineering Institute for Global Health Research and Technology, National University of Singapore, Singapore 117599, Singapore.
¹¹Division of Oral Biology and Medicine and the Jane and Jerry Weintraub Center for Reconstructive Biotechnology, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.

↵*Corresponding author. Email: csikce{at}nus.edu.sg

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Science Translational Medicine 08 Aug 2018:
Vol. 10, Issue 453, eaan0941
DOI: 10.1126/scitranslmed.aan0941

Masturah Bte Mohd Abdul Rashid

Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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Tan Boon Toh

Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.

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Lissa Hooi

Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.

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Aleidy Silva

Department of Mechanical Engineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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ORCID record for Aleidy Silva

Yanzhou Zhang

Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.

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Pei Fang Tan

Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.

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Ai Ling Teh

Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.

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Neerja Karnani

Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.

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Sudhakar Jha

Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.

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Chih-Ming Ho

Department of Mechanical Engineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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Wee Joo Chng

Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119228, Singapore.

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Dean Ho

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.Bioengineering Institute for Global Health Research and Technology, National University of Singapore, Singapore 117599, Singapore.Division of Oral Biology and Medicine and the Jane and Jerry Weintraub Center for Reconstructive Biotechnology, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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Edward Kai-Hua Chow

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For correspondence: csikce@nus.edu.sg

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