Research ArticleCancer
Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP)
- View ORCID ProfileMasturah Bte Mohd Abdul Rashid1,2,
- View ORCID ProfileTan Boon Toh1,
- Lissa Hooi1,
- View ORCID ProfileAleidy Silva3,
- View ORCID ProfileYanzhou Zhang1,
- View ORCID ProfilePei Fang Tan4,
- Ai Ling Teh4,
- Neerja Karnani4,5,
- Sudhakar Jha1,5,
- View ORCID ProfileChih-Ming Ho3,6,7,
- View ORCID ProfileWee Joo Chng1,8,
- View ORCID ProfileDean Ho2,6,7,9,10,11 and
- View ORCID ProfileEdward Kai-Hua Chow1,2,*
- 1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
- 2Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
- 3Department of Mechanical Engineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
- 4Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.
- 5Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
- 6Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
- 7Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
- 8Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119228, Singapore.
- 9Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.
- 10Bioengineering Institute for Global Health Research and Technology, National University of Singapore, Singapore 117599, Singapore.
- 11Division of Oral Biology and Medicine and the Jane and Jerry Weintraub Center for Reconstructive Biotechnology, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
- ↵*Corresponding author. Email: csikce{at}nus.edu.sg
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Science Translational Medicine 08 Aug 2018:
Vol. 10, Issue 453, eaan0941
DOI: 10.1126/scitranslmed.aan0941
Vol. 10, Issue 453, eaan0941
DOI: 10.1126/scitranslmed.aan0941
Masturah Bte Mohd Abdul Rashid
1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
2Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Tan Boon Toh
1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Lissa Hooi
1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Aleidy Silva
3Department of Mechanical Engineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yanzhou Zhang
1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Pei Fang Tan
4Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.
Ai Ling Teh
4Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.
Neerja Karnani
4Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.
5Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Sudhakar Jha
1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
5Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Chih-Ming Ho
3Department of Mechanical Engineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
6Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
7Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Wee Joo Chng
1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
8Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119228, Singapore.
Dean Ho
2Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
6Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
7Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
9Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.
10Bioengineering Institute for Global Health Research and Technology, National University of Singapore, Singapore 117599, Singapore.
11Division of Oral Biology and Medicine and the Jane and Jerry Weintraub Center for Reconstructive Biotechnology, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Edward Kai-Hua Chow
1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
2Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
