Contents
08 August 2018
Vol 10, Issue 453
Vol 10, Issue 453
Focus
- Dietary regulation of the origins of cancer
Understanding how diet and nutrients instruct intestinal stem cells and their daughter cells will provide insights into the beginnings of intestinal cancers.
- A genome-wide net to catch and understand cancer
Genome-scale forward genetic screens elucidate the genetic basis of therapeutic resistance, tumor evolution, and metastasis in diverse human cancers.
Research Articles
- Laminin 511 is a target antigen in autoimmune pancreatitis
The extracellular matrix protein laminin 511 is an autoantigen involved in the pathophysiology of autoimmune pancreatitis.
- Thy-1 (CD90) promotes bone formation and protects against obesity
Thy-1 on mesenchymal stem cells promotes osteogenesis while inhibiting adipogenesis and obesity.
- Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP)
A drug discovery and optimization platform uncovered effective therapeutic combinations for bortezomib-resistant multiple myeloma.
- MicroRNA-30c-5p modulates neuropathic pain in rodents
miR-30c-5p expression modulates pain in rodent models of nerve injury and is overexpressed in patients with neuropathic pain due to leg ischemia.
Editors' Choice
- Therapy going viral
Virus-loaded microparticles can successfully treat lung infections in mice.
- A novel neurostimulation strategy for facilitating fear regulation
Transcranial magnetic stimulation targeting a human homolog of a rodent fear regulation circuit enhances extinction learning in healthy human subjects.
- Unsplicing senescence
The secretion of protumorigenic factors by senescent cells is controlled by alternative splicing and can be targeted in cancer.
About The Cover
ONLINE COVER Souping Up Cancer Research. This image depicts a variety of cancer-associated genes, represented as cans of soup, illustrating the work of the joint winners of this year's AAAS Martin and Rose Wachtel Cancer Research Award: Neville Sanjana, who uses CRISPR/Cas9 screening to identify cancer genes, and Ömer Yilmaz, who studies the influence of diet on cancer risk. The winners discuss their work in a pair of Focus articles and will each present a lecture based on his research on Friday, 10 August 2018, at the National Institutes of Health. [CREDIT: CHRISTIAN STOLTE/NEW YORK GENOME CENTER. IMAGE DERIVED FROM ARTWORK © 2018 THE ANDY WARHOL FOUNDATION FOR THE VISUAL ARTS, INC.]