Research ArticleFragile X Syndrome
The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling
- Zhenjie Zhang1,*,
- Samuele G. Marro2,3,*,
- Yingsha Zhang4,*,
- Kristin L. Arendt1,
- Christopher Patzke4,
- Bo Zhou4,
- Tyler Fair2,3,
- Nan Yang2,3,
- Thomas C. Südhof4,5,†,
- Marius Wernig2,3,† and
- Lu Chen1,†
- 1Departments of Neurosurgery, and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305–5453, USA.
- 2Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
- 3Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
- 4Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
- 5Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
- ↵†Corresponding author. Email: luchen1{at}stanford.edu (L.C.); wernig{at}stanford.edu (M.W.); tcs1{at}stanford.edu (T.C.S.)
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Science Translational Medicine 01 Aug 2018:
Vol. 10, Issue 452, eaar4338
DOI: 10.1126/scitranslmed.aar4338
