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Research ArticleFragile X Syndrome
The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling
- View ORCID ProfileZhenjie Zhang1,*,
- View ORCID ProfileSamuele G. Marro2,3,*,
- Yingsha Zhang4,*,
- View ORCID ProfileKristin L. Arendt1,
- Christopher Patzke4,
- Bo Zhou4,
- Tyler Fair2,3,
- Nan Yang2,3,
- View ORCID ProfileThomas C. Südhof4,5,†,
- Marius Wernig2,3,† and
- View ORCID ProfileLu Chen1,†
- 1Departments of Neurosurgery, and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305–5453, USA.
- 2Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
- 3Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
- 4Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
- 5Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
- ↵†Corresponding author. Email: luchen1{at}stanford.edu (L.C.); wernig{at}stanford.edu (M.W.); tcs1{at}stanford.edu (T.C.S.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 01 Aug 2018:
Vol. 10, Issue 452, eaar4338
DOI: 10.1126/scitranslmed.aar4338
Vol. 10, Issue 452, eaar4338
DOI: 10.1126/scitranslmed.aar4338
Zhenjie Zhang
1Departments of Neurosurgery, and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305–5453, USA.
Samuele G. Marro
2Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
3Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
Yingsha Zhang
4Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
Kristin L. Arendt
1Departments of Neurosurgery, and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305–5453, USA.
Christopher Patzke
4Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
Bo Zhou
4Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
Tyler Fair
2Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
3Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
Nan Yang
2Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
3Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
Thomas C. Südhof
4Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
5Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
Marius Wernig
2Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
3Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
Lu Chen
1Departments of Neurosurgery, and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305–5453, USA.
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