Research ArticleFragile X Syndrome

The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling

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Science Translational Medicine  01 Aug 2018:
Vol. 10, Issue 452, eaar4338
DOI: 10.1126/scitranslmed.aar4338

Article Information

vol. 10 no. 452

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History: 
  • Received for publication November 7, 2017
  • Accepted for publication July 12, 2018
  • .

Author Information

  1. Zhenjie Zhang1,*,
  2. Samuele G. Marro2,3,*,
  3. Yingsha Zhang4,*,
  4. Kristin L. Arendt1,
  5. Christopher Patzke4,
  6. Bo Zhou4,
  7. Tyler Fair2,3,
  8. Nan Yang2,3,
  9. Thomas C. Südhof4,5,,
  10. Marius Wernig2,3, and
  11. Lu Chen1,
  1. 1Departments of Neurosurgery, and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305–5453, USA.
  2. 2Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
  3. 3Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
  4. 4Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
  5. 5Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.
  1. Corresponding author. Email: luchen1{at}stanford.edu (L.C.); wernig{at}stanford.edu (M.W.); tcs1{at}stanford.edu (T.C.S.)
    • * These authors contributed equally to this work.

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