Research ArticleImaging

Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone

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Science Translational Medicine  01 Aug 2018:
Vol. 10, Issue 452, eaao5726
DOI: 10.1126/scitranslmed.aao5726

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Bone tumors revealed

Noninvasive imaging can help monitor cancer metastasis and tumor-stroma interactions but is challenging for thick, dense tissues such as bone. Dondossola et al. studied prostate cancer metastasis to bone using tissue engineering and intravital multiphoton microscopy in mice. A skin window overlaying implanted engineered bone constructs injected with cancer cells allowed for observation of osteolysis in the bone constructs, with osteoclasts localized at the tumor-bone interface. Treatment with zoledronic acid slowed osteoclast activity (bone resorption) without affecting cancer growth. This engineered bone and imaging method gives a glimpse into tumor-bone interactions that could be useful to test therapies for bone remodeling and cancer metastasis.