Research ArticleIMMUNODIAGNOSTICS

Epigenetic immune cell counting in human blood samples for immunodiagnostics

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Science Translational Medicine  01 Aug 2018:
Vol. 10, Issue 452, eaan3508
DOI: 10.1126/scitranslmed.aan3508

Article Information

vol. 10 no. 452

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History: 
  • Received for publication April 5, 2017
  • Resubmitted February 23, 2018
  • Accepted for publication June 18, 2018
  • .

Author Information

  1. Udo Baron1,*,
  2. Jeannette Werner1,*,
  3. Konstantin Schildknecht1,*,
  4. Janika J. Schulze1,*,
  5. Andargaschew Mulu2,3,
  6. Uwe-Gerd Liebert2,
  7. Ulrich Sack4,
  8. Carsten Speckmann5,
  9. Manfred Gossen6,7,
  10. Ronald J. Wong8,
  11. David K. Stevenson8,
  12. Nina Babel9,
  13. Dirk Schürmann10,
  14. Tina Baldinger1,
  15. Rosa Bacchetta11,
  16. Andreas Grützkau12,
  17. Stephan Borte13,14, and
  18. Sven Olek1,
  1. 1Ivana Türbachova Laboratory for Epigenetics, Epiontis GmbH, Precision for Medicine Group, 12489 Berlin, Germany.
  2. 2Institute of Virology, Faculty of Medicine, University Leipzig, 04009 Leipzig, Germany.
  3. 3Armauer Hansen Research Institute, 1005 Addis Ababa, Ethiopia.
  4. 4Institute of Clinical Immunology, Faculty of Medicine, University Leipzig, 04009 Leipzig, Germany.
  5. 5Center for Chronic Immunodeficiency and Department of Pediatric and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany.
  6. 6Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany.
  7. 7Berlin-Brandenburg Center for Regenerative Therapies, 13353 Berlin, Germany.
  8. 8Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  9. 9Marienhospital Herne, Medizinische Klinik I, Universität Bochum, 44625 Herne, Germany.
  10. 10Charité Universitätsmedizin Berlin, 13353 Berlin, Germany.
  11. 11Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA.
  12. 12Deutsches Rheuma-Forschungszentrum, an Institute of the Leibniz Association, Immune Monitoring Core Facility, 10117 Berlin, Germany.
  13. 13ImmunoDeficiencyCenter Leipzig, Municipal Hospital St. Georg Leipzig, 04129 Leipzig, Germany.
  14. 14Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge at Karolinska Institutet, 14186 Stockholm, Sweden.
  1. Corresponding author. Email: sven.olek{at}epiontis.com (S.O.); stephan.borte{at}idcl.de (S.B.)
    • * These authors contributed equally to this work.

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