01 August 2018
Vol 10, Issue 452

About The Cover

Cover image expansion

ONLINE COVER Breathing New Life into Lungs. Gas exchange in the lungs depends on multiple specialized cell types maintaining tissue architecture in compliant extracellular matrix, making bioengineering lungs a challenge. Nichols et al. used nanoparticle-released growth factors to help seed pig lung scaffolds with autologous cells, and used bioreactor culture (shown here) to provide adequate oxygenation to the organs before implantation. Implanted lungs became aerated and vascularized, with native-like microbiomes developing in the bioengineered lungs in immunocompetent pigs. Recipient pigs respired for months after implantation without evidence of organ rejection and the bioengineered lungs continued to develop even after implantation. The duration of lung function and vascularization after implantation in this large animal model are advances in lung tissue engineering. [CREDIT: NICHOLS ET AL./SCIENCE TRANSLATIONAL MEDICINE]