Contents
01 August 2018
Vol 10, Issue 452
Vol 10, Issue 452
Research Articles
- Production and transplantation of bioengineered lung into a large-animal model
Nanoparticle delivery of growth factors promotes capillary development in bioengineered lungs during bioreactor culture and transplantation in a pig model.
- Epigenetic immune cell counting in human blood samples for immunodiagnostics
Epigenetic immune cell counting provides a potentially more robust platform to diagnose immune defects in adults and newborns.
- Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone
A skin window enables noninvasive, longitudinal monitoring of cancer growth and therapy response in tissue-engineered bone in mice.
- The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling
Inactivation of the Fmr1 gene that is mutated in fragile X syndrome leads to loss of retinoic acid–mediated homeostatic plasticity in human neurons.
Report
- Increasing tolerance of hospital Enterococcus faecium to handwash alcohols
The multidrug-resistant bacterium Enterococcus faecium has become increasingly tolerant to the alcohols in hospital disinfectants.
Editors' Choice
- Self-sustained seizure inhibition
Gene therapy with a glutamate-sensitive chloride channel allows effective local inhibition of focal seizures without affecting normal brain function in rats.
- Drug smuggling microparticles play dress-up
Hemolysate coating prolongs circulation of red blood cell–shaped microparticles.
- From diabetes to cancer: Glucose makes the difference
High glucose decreases TET2 via AMPK and leads to increased tumorigenesis.
About The Cover
ONLINE COVER Breathing New Life into Lungs. Gas exchange in the lungs depends on multiple specialized cell types maintaining tissue architecture in compliant extracellular matrix, making bioengineering lungs a challenge. Nichols et al. used nanoparticle-released growth factors to help seed pig lung scaffolds with autologous cells, and used bioreactor culture (shown here) to provide adequate oxygenation to the organs before implantation. Implanted lungs became aerated and vascularized, with native-like microbiomes developing in the bioengineered lungs in immunocompetent pigs. Recipient pigs respired for months after implantation without evidence of organ rejection and the bioengineered lungs continued to develop even after implantation. The duration of lung function and vascularization after implantation in this large animal model are advances in lung tissue engineering. [CREDIT: NICHOLS ET AL./SCIENCE TRANSLATIONAL MEDICINE]