Research ArticleEYE DISEASE

Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice

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Science Translational Medicine  25 Jul 2018:
Vol. 10, Issue 451, eaas9164
DOI: 10.1126/scitranslmed.aas9164

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Inflammatory obstruction in the eye

Obstruction of eyelid glands called meibomian glands (MGs) is a risk factor for developing chronic inflammation of the eyelids. The function of these glands is to secrete oils onto the surface of the eye. The etiology of MG obstruction is not completely understood. Now, Reyes et al. have discovered that polymorphonuclear neutrophils (PMNs) promoted MG obstruction in a mouse model of inflammatory eye disease. Furthermore, PMNs were increased in tears of patients with MG obstruction, and PMN number correlated with the severity of the obstruction. The data suggest that PMNs might contribute to the etiology of MG obstruction in inflammatory eyelid disease.