Transcriptional signature primes human oral mucosa for rapid wound healing

Ramiro Iglesias-Bartolome; Akihiko Uchiyama; Alfredo A. Molinolo; Loreto Abusleme; Stephen R. Brooks; Juan Luis Callejas-Valera; Dean Edwards; Colleen Doci; Marie-Liesse Asselin-Labat; Mark W. Onaitis; Niki M. Moutsopoulos; J. Silvio Gutkind; Maria I. Morasso

doi:10.1126/scitranslmed.aap8798

Research ArticleWound Healing

Transcriptional signature primes human oral mucosa for rapid wound healing

View ORCID ProfileRamiro Iglesias-Bartolome¹,²,*,
Akihiko Uchiyama¹,
View ORCID ProfileAlfredo A. Molinolo²,³,
View ORCID ProfileLoreto Abusleme⁴,
Stephen R. Brooks⁵,
View ORCID ProfileJuan Luis Callejas-Valera²,³,
View ORCID ProfileDean Edwards²,
View ORCID ProfileColleen Doci²,†,
View ORCID ProfileMarie-Liesse Asselin-Labat⁶,
Mark W. Onaitis⁶,
Niki M. Moutsopoulos⁴,
View ORCID ProfileJ. Silvio Gutkind ²,³,‡ and
View ORCID ProfileMaria I. Morasso ¹,‡

¹Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.
²Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.
³Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
⁴Oral Immunity and Inflammation Unit, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.
⁵Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.
⁶Moores Cancer Center, University California, San Diego, La Jolla, CA 92093, USA.

↵‡Corresponding author. Email: morasso{at}nih.gov (M.I.M.); sgutkind{at}ucsd.edu (J.S.G.)

↵* Present address: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
↵† Present address: College of Arts and Sciences, Marian University, Indianapolis, IN 46222, USA.

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Science Translational Medicine 25 Jul 2018:
Vol. 10, Issue 451, eaap8798
DOI: 10.1126/scitranslmed.aap8798

Ramiro Iglesias-Bartolome

1Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.

2Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

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ORCID record for Ramiro Iglesias-Bartolome

Akihiko Uchiyama

1Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.

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Alfredo A. Molinolo

2Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

3Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

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ORCID record for Alfredo A. Molinolo

Loreto Abusleme

4Oral Immunity and Inflammation Unit, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

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Stephen R. Brooks

5Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.

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Juan Luis Callejas-Valera

2Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

3Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

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ORCID record for Juan Luis Callejas-Valera

Dean Edwards

2Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

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Colleen Doci

2Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

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Marie-Liesse Asselin-Labat

6Moores Cancer Center, University California, San Diego, La Jolla, CA 92093, USA.

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Mark W. Onaitis

6Moores Cancer Center, University California, San Diego, La Jolla, CA 92093, USA.

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Niki M. Moutsopoulos

4Oral Immunity and Inflammation Unit, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

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J. Silvio Gutkind

2Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

3Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

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For correspondence: morasso@nih.gov sgutkind@ucsd.edu

Maria I. Morasso

1Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.

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ORCID record for Maria I. Morasso
For correspondence: morasso@nih.gov sgutkind@ucsd.edu

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Transcriptional signature primes human oral mucosa for rapid wound healing

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