Transcriptional signature primes human oral mucosa for rapid wound healing

Ramiro Iglesias-Bartolome; Akihiko Uchiyama; Alfredo A. Molinolo; Loreto Abusleme; Stephen R. Brooks; Juan Luis Callejas-Valera; Dean Edwards; Colleen Doci; Marie-Liesse Asselin-Labat; Mark W. Onaitis; Niki M. Moutsopoulos; J. Silvio Gutkind; Maria I. Morasso

doi:10.1126/scitranslmed.aap8798

Research ArticleWound Healing

Transcriptional signature primes human oral mucosa for rapid wound healing

Ramiro Iglesias-Bartolome¹,²,*,
Akihiko Uchiyama¹,
Alfredo A. Molinolo²,³,
Loreto Abusleme⁴,
Stephen R. Brooks⁵,
Juan Luis Callejas-Valera²,³,
Dean Edwards²,
Colleen Doci²,†,
Marie-Liesse Asselin-Labat⁶,
Mark W. Onaitis⁶,
Niki M. Moutsopoulos⁴,
J. Silvio Gutkind ²,³,‡ and
Maria I. Morasso ¹,‡

¹Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.
²Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.
³Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
⁴Oral Immunity and Inflammation Unit, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.
⁵Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.
⁶Moores Cancer Center, University California, San Diego, La Jolla, CA 92093, USA.

↵‡Corresponding author. Email: morasso{at}nih.gov (M.I.M.); sgutkind{at}ucsd.edu (J.S.G.)

↵* Present address: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
↵† Present address: College of Arts and Sciences, Marian University, Indianapolis, IN 46222, USA.

See allHide authors and affiliations

Science Translational Medicine 25 Jul 2018:
Vol. 10, Issue 451, eaap8798
DOI: 10.1126/scitranslmed.aap8798

Ramiro Iglesias-Bartolome

1Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.

2Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ramiro Iglesias-Bartolome

Akihiko Uchiyama

1Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alfredo A. Molinolo

2Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

3Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Alfredo A. Molinolo

Loreto Abusleme

4Oral Immunity and Inflammation Unit, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Loreto Abusleme

Stephen R. Brooks

5Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Juan Luis Callejas-Valera

2Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

3Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Juan Luis Callejas-Valera

Dean Edwards

2Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Dean Edwards

Colleen Doci

2Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Colleen Doci

Marie-Liesse Asselin-Labat

6Moores Cancer Center, University California, San Diego, La Jolla, CA 92093, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Marie-Liesse Asselin-Labat

Mark W. Onaitis

6Moores Cancer Center, University California, San Diego, La Jolla, CA 92093, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Niki M. Moutsopoulos

4Oral Immunity and Inflammation Unit, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

J. Silvio Gutkind

2Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

3Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for J. Silvio Gutkind
For correspondence: morasso@nih.gov sgutkind@ucsd.edu

Maria I. Morasso

1Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Maria I. Morasso
For correspondence: morasso@nih.gov sgutkind@ucsd.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Transcriptional signature primes human oral mucosa for rapid wound healing

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools