25 July 2018
Vol 10, Issue 451

About The Cover

Cover image expansion

ONLINE COVER Hastened Healing. Wounds in the human mouth, such as this biopsy taken from injured oral mucosa and stained for the epithelial markers keratin 6 (green) and keratin 5 (red), heal faster than wounds in other locations on the body. Iglesias-Bartolome et al. used transcriptomics to study differences in gene expression during wound healing, using paired oral and skin biopsies from healthy human subjects. They found several transcription factors that were up-regulated in oral mucosa compared to skin. Overexpressing one of these factors in a mouse model of skin wounding improved healing. These findings could eventually help inform targeted therapy design for wound healing. [CREDIT: IGLESIAS-BARTOLOME ET AL./SCIENCE TRANSLATIONAL MEDICINE]