Contents
25 July 2018
Vol 10, Issue 451
Vol 10, Issue 451
Research Articles
- Transcriptional signature primes human oral mucosa for rapid wound healing
Transcriptional profiling of human cutaneous and oral wound healing reveals pathways involved in rapid wound resolution.
- Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis
Platelet microparticles from patients with systemic sclerosis prompt endothelial cell activation, neutrophil recruitment, and lung fibrosis.
- Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice
Neutrophils obstruct the meibomian gland in a mouse model of inflammatory eye disease and correlate with disease severity in patients with meibomian gland dysfunction.
- Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy
Inhibition of activin signaling enhances the efficacy and safety of platinum chemotherapy in lung adenocarcinoma models.
- LRRK2 activation in idiopathic Parkinson’s disease
Wild-type LRRK2 is activated in nigrostriatal dopamine neurons in idiopathic Parkinson’s disease and plays a pathogenic role in this neurodegenerative disorder.
Editors' Choice
- Patient-derived organoids: Are PDOs the new PDX?
Patient-derived organoids in pancreatic cancer maintain genotypic, transcriptomic, and potentially phenotypic responses to chemotherapy of the primary tumor.
- The lymphatic border patrol outwits inflammatory cells in myocardial infarction
Lymphangiogenesis modulates inflammation by clearing immune cells in the infarcted heart in a lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1)–dependent process to ameliorate cardiac dysfunction.
- Convection-enhanced delivery of drugs for deadliest pediatric brain tumors
Convection-enhanced delivery in the brainstem of children with tumors is clinically feasible and safe within defined parameters.
- Blame the gut for a fatty liver!
Microbiota dysbiosis may play a key role in triggering hepatic steatosis in nondiabetic obese women.
Erratum
About The Cover
ONLINE COVER Hastened Healing. Wounds in the human mouth, such as this biopsy taken from injured oral mucosa and stained for the epithelial markers keratin 6 (green) and keratin 5 (red), heal faster than wounds in other locations on the body. Iglesias-Bartolome et al. used transcriptomics to study differences in gene expression during wound healing, using paired oral and skin biopsies from healthy human subjects. They found several transcription factors that were up-regulated in oral mucosa compared to skin. Overexpressing one of these factors in a mouse model of skin wounding improved healing. These findings could eventually help inform targeted therapy design for wound healing. [CREDIT: IGLESIAS-BARTOLOME ET AL./SCIENCE TRANSLATIONAL MEDICINE]