Research ArticleCancer

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

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Science Translational Medicine  18 Jul 2018:
Vol. 10, Issue 450, eaaq1093
DOI: 10.1126/scitranslmed.aaq1093

Article Information

vol. 10 no. 450

PubMed: 
Print ISSN: 
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History: 
  • Received for publication October 3, 2017
  • Resubmitted April 21, 2018
  • Accepted for publication June 8, 2018
  • .

Author Information

  1. Otto Kauko1,2,3,*,
  2. Caitlin M. O’Connor4,,
  3. Evgeny Kulesskiy5,,
  4. Jaya Sangodkar6,
  5. Anna Aakula1,
  6. Sudeh Izadmehr6,
  7. Laxman Yetukuri1,
  8. Bhagwan Yadav5,
  9. Artur Padzik1,
  10. Teemu Daniel Laajala5,7,
  11. Pekka Haapaniemi1,
  12. Majid Momeny1,
  13. Taru Varila1,
  14. Michael Ohlmeyer6,
  15. Tero Aittokallio5,7,
  16. Krister Wennerberg5,,
  17. Goutham Narla4,§ and
  18. Jukka Westermarck1,2,§
  1. 1Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
  2. 2Institute of Biomedicine, University of Turku, 20520 Turku, Finland.
  3. 3TuBS and TuDMM Doctoral Programmes, University of Turku, 20520 Turku, Finland.
  4. 4Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106–7285, USA.
  5. 5Institute for Molecular Medicine Finland, University of Helsinki, 00014 Helsinki, Finland.
  6. 6Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  7. 7Department of Mathematics and Statistics, University of Turku, 20520 Turku, Finland.
  1. Corresponding author. Email: jukwes{at}utu.fi
    • * Present address: Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden.

    • These authors contributed equally to this work.

    • Present address: Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.

    • § These authors contributed equally to this work.

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