18 July 2018
Vol 10, Issue 450

About The Cover

Cover image expansion

ONLINE COVER Going Pain-Free with Botox. Depicted here is a molecule of botulinum toxin A, a neurotoxic product of the bacterium Clostridium botulinum that exerts its toxic effect by inhibiting acetylcholine release from neurons. This toxin is also known for its cosmetic applications (botox). Now, Maiarù et al. show in rodents that this toxin can be used for treating chronic pain. The authors developed botulinum toxin A–conjugated molecules that silenced specific pain–associated neuronal populations in two rodent models of pain. One injection of the toxin-conjugates exerted long lasting analgesia comparable to that of opioid treatments, suggesting that these molecules might be an effective alternative to opioids for treating pain. [CREDIT: DR_MICROBE/ISTOCK]