Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils

Christian Wrobel; Alexander Dieter; Antoine Huet; Daniel Keppeler; Carlos J. Duque-Afonso; Christian Vogl; Gerhard Hoch; Marcus Jeschke; Tobias Moser

doi:10.1126/scitranslmed.aao0540

Research ArticleOPTOGENETICS

Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils

Christian Wrobel¹,²,³,*,†,
Alexander Dieter¹,⁴,⁵,*,
Antoine Huet¹,⁵,‡,
Daniel Keppeler¹,⁴,‡,
Carlos J. Duque-Afonso¹,⁴,
Christian Vogl²,⁶,
Gerhard Hoch¹,²,⁵,
Marcus Jeschke¹,⁵,§ and
Tobias Moser ¹,²,⁴,⁵,⁷,⁸,§

¹Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.
²Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.
³Department of Otorhinolaryngology, Head and Neck Surgery, Ruhr University Bochum, St. Elisabeth Hospital, 44787 Bochum, Germany.
⁴Göttingen Graduate School for Neurosciences and Molecular Biosciences, University of Göttingen, 37075 Göttingen, Germany.
⁵Auditory Neuroscience and Optogenetics Group, German Primate Center, 37077 Göttingen, Germany.
⁶Presynaptogenesis and Intracellular Transport in Hair Cells Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.
⁷Bernstein Center for Computational Neuroscience, University of Göttingen, 37077 Göttingen, Germany.
⁸Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, 37075 Göttingen, Germany.

↵§Corresponding author. Email: marcus.jeschke{at}med.uni-goettingen.de (M.J.); tmoser{at}gwdg.de (T.M.)

↵* These authors contributed equally to this work.
↵† Present address: Department of Otorhinolaryngology and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.
↵‡ These authors contributed equally to this work.

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Science Translational Medicine 11 Jul 2018:
Vol. 10, Issue 449, eaao0540
DOI: 10.1126/scitranslmed.aao0540

Christian Wrobel

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.Department of Otorhinolaryngology, Head and Neck Surgery, Ruhr University Bochum, St. Elisabeth Hospital, 44787 Bochum, Germany.

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Alexander Dieter

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.Göttingen Graduate School for Neurosciences and Molecular Biosciences, University of Göttingen, 37075 Göttingen, Germany.Auditory Neuroscience and Optogenetics Group, German Primate Center, 37077 Göttingen, Germany.

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Antoine Huet

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.Auditory Neuroscience and Optogenetics Group, German Primate Center, 37077 Göttingen, Germany.

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Daniel Keppeler

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Carlos J. Duque-Afonso

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Christian Vogl

Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.Presynaptogenesis and Intracellular Transport in Hair Cells Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.

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Gerhard Hoch

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Marcus Jeschke

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For correspondence: marcus.jeschke@med.uni-goettingen.de tmoser@gwdg.de

Tobias Moser

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.Göttingen Graduate School for Neurosciences and Molecular Biosciences, University of Göttingen, 37075 Göttingen, Germany.Auditory Neuroscience and Optogenetics Group, German Primate Center, 37077 Göttingen, Germany.Bernstein Center for Computational Neuroscience, University of Göttingen, 37077 Göttingen, Germany.Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, 37075 Göttingen, Germany.

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For correspondence: marcus.jeschke@med.uni-goettingen.de tmoser@gwdg.de

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Virus-mediated expression of channelrhodopsin enables optogenetic stimulation of auditory pathways and restoration of auditory-driven behavior in deaf adult gerbils.

Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils

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