Research ArticleOPTOGENETICS

Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils

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Science Translational Medicine  11 Jul 2018:
Vol. 10, Issue 449, eaao0540
DOI: 10.1126/scitranslmed.aao0540

Article Information

vol. 10 no. 449

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History: 
  • Received for publication June 9, 2017
  • Resubmitted November 17, 2017
  • Accepted for publication June 19, 2018
  • .

Author Information

  1. Christian Wrobel1,2,3,*,,
  2. Alexander Dieter1,4,5,*,
  3. Antoine Huet1,5,,
  4. Daniel Keppeler1,4,,
  5. Carlos J. Duque-Afonso1,4,
  6. Christian Vogl2,6,
  7. Gerhard Hoch1,2,5,
  8. Marcus Jeschke1,5,§ and
  9. Tobias Moser1,2,4,5,7,8,§
  1. 1Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.
  2. 2Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.
  3. 3Department of Otorhinolaryngology, Head and Neck Surgery, Ruhr University Bochum, St. Elisabeth Hospital, 44787 Bochum, Germany.
  4. 4Göttingen Graduate School for Neurosciences and Molecular Biosciences, University of Göttingen, 37075 Göttingen, Germany.
  5. 5Auditory Neuroscience and Optogenetics Group, German Primate Center, 37077 Göttingen, Germany.
  6. 6Presynaptogenesis and Intracellular Transport in Hair Cells Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.
  7. 7Bernstein Center for Computational Neuroscience, University of Göttingen, 37077 Göttingen, Germany.
  8. 8Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, 37075 Göttingen, Germany.
  1. §Corresponding author. Email: marcus.jeschke{at}med.uni-goettingen.de (M.J.); tmoser{at}gwdg.de (T.M.)
    • * These authors contributed equally to this work.

    • Present address: Department of Otorhinolaryngology and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.

    • These authors contributed equally to this work.

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