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MEK inhibition induces MYOG and remodels super-enhancers in RAS-driven rhabdomyosarcoma

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Science Translational Medicine  04 Jul 2018:
Vol. 10, Issue 448, eaan4470
DOI: 10.1126/scitranslmed.aan4470

Article Information

vol. 10 no. 448

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 26, 2017
  • Accepted for publication June 6, 2018
  • .

Author Information

  1. Marielle E. Yohe1,2,*,,
  2. Berkley E. Gryder1,,
  3. Jack F. Shern2,
  4. Young K. Song1,
  5. Hsien-Chao Chou1,
  6. Sivasish Sindiri1,
  7. Arnulfo Mendoza2,
  8. Rajesh Patidar1,
  9. Xiaohu Zhang3,
  10. Rajarashi Guha3,,
  11. Donna Butcher4,
  12. Kristine A. Isanogle5,
  13. Christina M. Robinson5,
  14. Xiaoling Luo6,
  15. Jin-Qiu Chen6,
  16. Ashley Walton1,
  17. Parirokh Awasthi5,
  18. Elijah F. Edmondson4,
  19. Simone Difilippantonio5,
  20. Jun S. Wei1,
  21. Keji Zhao7,
  22. Marc Ferrer3,
  23. Craig J. Thomas3 and
  24. Javed Khan1,*
  1. 1Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  2. 2Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  3. 3Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Bethesda, MD 20892, USA.
  4. 4Pathology/Histotechnology Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, MD 21702, USA.
  5. 5Laboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, MD 21701, USA.
  6. 6Collaborative Protein Technology Resource, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  7. 7Systems Biology Center, National Heart Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
  1. *Corresponding author. Email: yoheme{at}mail.nih.gov (M.E.Y.); khanjav{at}mail.nih.gov (J.K.)
    • These authors contributed equally to this work.

    • Present address: Vertex Pharmaceuticals, Boston, MA 02210, USA.

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