Research ArticleNEUROPATHOLOGY

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

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Science Translational Medicine  04 Jul 2018:
Vol. 10, Issue 448, eaam9507
DOI: 10.1126/scitranslmed.aam9507

Article Information

vol. 10 no. 448

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History: 
  • Received for publication February 9, 2017
  • Resubmitted January 31, 2018
  • Accepted for publication June 8, 2018
  • .

Author Information

  1. Rikesh M. Rajani1,
  2. Sophie Quick1,
  3. Silvie R. Ruigrok1,
  4. Delyth Graham2,
  5. Sarah E. Harris3,
  6. Benjamin F. J. Verhaaren4,5,
  7. Myriam Fornage5,6,
  8. Sudha Seshadri5,7,
  9. Santosh S. Atanur8,
  10. Anna F. Dominiczak2,
  11. Colin Smith9,
  12. Joanna M. Wardlaw10 and
  13. Anna Williams1,*
  1. 1Medical Research Council (MRC) Centre for Regenerative Medicine and UK Dementia Research Institute, University of Edinburgh, Edinburgh EH16 4UU, UK.
  2. 2Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  3. 3Centre for Cognitive Ageing and Cognitive Epidemiology and MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2LF, UK.
  4. 4Erasmus Medical Centre, 3015 CE Rotterdam, Netherlands.
  5. 5Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE).
  6. 6Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.
  7. 7Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.
  8. 8Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2LF, UK.
  9. 9Academic Neuropathology, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
  10. 10Brain Research Imaging Centre, Centre for Clinical Brain Sciences, and UK Dementia Research Institute, University of Edinburgh, Edinburgh EH16 4SB, UK.
  1. *Corresponding author. Email: anna.williams{at}ed.ac.uk

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