04 July 2018
Vol 10, Issue 448

About The Cover

Cover image expansion

ONLINE COVER Brighter Horizons for an HIV Vaccine. Despite decades of intensive research, an effective vaccine against HIV remains elusive. An ideal vaccine would generate broadly neutralizing antibodies to cope with viral diversity, which would require naive B cells to embark on a series of activation and maturation steps. Havenar-Daughton and colleagues investigated how human naive B cells recognized a structure-based HIV vaccine candidate. B cells that bound the vaccine protein used the same gene segments found in several potent broadly neutralizing antibodies that target a vulnerable portion of the virus. These results suggest that the vaccine candidate could stimulate the right type of B cell, bringing the dream of an HIV vaccine a bit closer to reality. [CREDIT: DANITA DELIMONT/GETTY IMAGES]