Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

Hyun Jae Lee; Athina Georgiadou; Michael Walther; Davis Nwakanma; Lindsay B. Stewart; Michael Levin; Thomas D. Otto; David J. Conway; Lachlan J. Coin; Aubrey J. Cunnington

doi:10.1126/scitranslmed.aar3619

Research ArticleMalaria

Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

Hyun Jae Lee¹,*,
Athina Georgiadou²,
Michael Walther³,
Davis Nwakanma³,
Lindsay B. Stewart⁴,
Michael Levin²,
Thomas D. Otto⁵,†,‡,
David J. Conway⁴,†,
Lachlan J. Coin¹,† and
Aubrey J. Cunnington ²,§

¹Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
²Section of Paediatrics, Imperial College, London W2 1PG, UK.
³Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, P.O. Box 273, Fajara, The Gambia.
⁴Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
⁵Wellcome Trust Sanger Centre, Hinxton, Cambridge CB10 1SA, UK.

↵§Corresponding author. Email: a.cunnington{at}imperial.ac.uk

↵* Present address: Queensland Institute of Medical Research Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, Queensland 4029, Australia.
↵† These authors contributed equally to this work.
↵‡ Present address: Centre of Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

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Science Translational Medicine 27 Jun 2018:
Vol. 10, Issue 447, eaar3619
DOI: 10.1126/scitranslmed.aar3619

Hyun Jae Lee

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.

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Athina Georgiadou

Section of Paediatrics, Imperial College, London W2 1PG, UK.

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Michael Walther

Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, P.O. Box 273, Fajara, The Gambia.

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Davis Nwakanma

Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, P.O. Box 273, Fajara, The Gambia.

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Lindsay B. Stewart

Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

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Michael Levin

Section of Paediatrics, Imperial College, London W2 1PG, UK.

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Thomas D. Otto

Wellcome Trust Sanger Centre, Hinxton, Cambridge CB10 1SA, UK.

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David J. Conway

Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

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Lachlan J. Coin

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.

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Aubrey J. Cunnington

Section of Paediatrics, Imperial College, London W2 1PG, UK.

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For correspondence: a.cunnington@imperial.ac.uk

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Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

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