Research ArticleHEPATITIS

Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection

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Science Translational Medicine  27 Jun 2018:
Vol. 10, Issue 447, eaap9328
DOI: 10.1126/scitranslmed.aap9328

Article Information

vol. 10 no. 447

PubMed: 
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History: 
  • Received for publication September 11, 2017
  • Resubmitted December 19, 2017
  • Accepted for publication May 14, 2018
  • .

Author Information

  1. Benjamin Y. Winer1,
  2. Elham Shirvani-Dastgerdi1,*,
  3. Yaron Bram2,*,
  4. Julie Sellau1,
  5. Benjamin E. Low3,
  6. Heath Johnson1,
  7. Tiffany Huang1,
  8. Gabriela Hrebikova1,
  9. Brigitte Heller1,
  10. Yael Sharon1,
  11. Katja Giersch4,
  12. Sherif Gerges1,
  13. Kathleen Seneca5,
  14. Mihai-Alexandru Pais1,
  15. Angela S. Frankel2,
  16. Luis Chiriboga6,
  17. John Cullen7,
  18. Ronald G. Nahass5,
  19. Marc Lutgehetmann8,
  20. Jared E. Toettcher1,
  21. Michael V. Wiles3,
  22. Robert E. Schwartz2 and
  23. Alexander Ploss1,
  1. 1Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA.
  2. 2Division of Gastroenterology and Hepatology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.
  3. 3Department of Technology Evaluation and Development, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609–1500 USA.
  4. 4Department of Internal Medicine, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  5. 5Infectious Disease Care, 105 Raider Boulevard, Hillsborough, NJ 08844, USA.
  6. 6Department of Pathology, New York University Medical Center, New York, NY 10016, USA.
  7. 7Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27607, USA.
  8. 8Institute of Microbiology, Virology and Hygiene, University Medical Hospital, Hamburg-Eppendorf, Hamburg, Germany.
  1. Corresponding author. Email: aploss{at}princeton.edu
    • * These authors contributed equally to this work.

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