Research ArticleHEPATITIS

Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection

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Science Translational Medicine  27 Jun 2018:
Vol. 10, Issue 447, eaap9328
DOI: 10.1126/scitranslmed.aap9328

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Diving into hepatitis delta virus

Although it is a major burden of hepatitis-related disease, there are no specific treatments for hepatitis delta virus (HDV), which depends on hepatitis B virus to replicate. Winer et al. developed a transgenic mouse model to study HDV and test therapeutic interventions. They observed immune responses and effects on the liver, as well as tested drug candidates. This model could help open up the pipeline for future HDV treatments.