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Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy

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Science Translational Medicine  27 Jun 2018:
Vol. 10, Issue 447, eaao4953
DOI: 10.1126/scitranslmed.aao4953

Article Information

vol. 10 no. 447

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History: 
  • Received for publication July 26, 2017
  • Resubmitted September 18, 2017
  • Accepted for publication January 26, 2018
  • .

Author Information

  1. Thomas C. Thannickal1,2,
  2. Joshi John1,2,
  3. Ling Shan1,2,
  4. Dick F. Swaab3,
  5. Ming-Fung Wu1,2,
  6. Lalini Ramanathan1,2,
  7. Ronald McGregor1,2,
  8. Keng-Tee Chew1,2,
  9. Marcia Cornford4,
  10. Akihiro Yamanaka5,
  11. Ayumu Inutsuka5,
  12. Rolf Fronczek6,7,
  13. Gert Jan Lammers6,7,
  14. Paul F. Worley8 and
  15. Jerome M. Siegel1,2,*
  1. 1Neuropsychiatric Institute and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  2. 2Neurobiology Research, Veterans Administration Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA.
  3. 3Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands.
  4. 4Department of Pathology, Harbor University of California, Los Angeles, Medical Center, Torrance, CA 90509, USA.
  5. 5Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
  6. 6Leiden University Medical Centre, Department of Neurology, Leiden, Netherlands.
  7. 7Sleep Wake Centre, Stichting Epilepsie Instellingen Nederland, Heemstede, Netherlands.
  8. 8The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  1. *Corresponding author. Email: jsiegel{at}ucla.edu

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