Contents
27 June 2018
Vol 10, Issue 447
Vol 10, Issue 447
Research Articles
- Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria
Host and parasite RNA sequencing is combined with parasite load estimates to reveal mechanisms associated with human severe malaria.
- Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection
An inbred mouse model for HDV infection can be used to study virally induced immune responses and for testing antiviral therapeutics.
- Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy
Heroin addiction is accompanied by an increase in detected hypocretin (orexin) neurons, and in narcoleptic mice deficient in these neurons, morphine can reverse cataplexy.
- Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas
Selective mislocalization of E2F7 in head and neck cancers drives anthracycline resistance and can be reversed.
Editors' Choice
- The hidden agenda for immune escape in colorectal cancer
Multi-omic studies reveal immune evasion profiles in colorectal cancer.
- A magnetic look into neuromodulation
Hydrogel containing magnetic microparticles allows for noninvasive and remote neuromodulation via magnetomechanical stimulation.
- Faulty fat cells linked to weight gain
Altered fat cell lipolysis predicts long-term weight gain and risk of type 2 diabetes.
About The Cover
ONLINE COVER A Deadly Duet. The molecular etiology of severe malaria is not well understood. Lee et al. sequenced the paired transcriptomes of 41 Gambian children with uncomplicated or severe malaria and their malaria-causing P. falciparum parasites. Shown here is a visualization of modules of genes with similar functional roles, as inferred by coexpression network analysis of the combined host and parasite genes from each patient. Also shown are module associations with different clinical characteristics of malaria severity. Some modules contain all human or all P. falciparum genes, whereas others contain genes from both species, reflecting possible co-regulation between host and parasite. [CREDIT: LEE ET AL./SCIENCE TRANSLATIONAL MEDICINE]