27 June 2018
Vol 10, Issue 447

About The Cover

Cover image expansion

ONLINE COVER A Deadly Duet. The molecular etiology of severe malaria is not well understood. Lee et al. sequenced the paired transcriptomes of 41 Gambian children with uncomplicated or severe malaria and their malaria-causing P. falciparum parasites. Shown here is a visualization of modules of genes with similar functional roles, as inferred by coexpression network analysis of the combined host and parasite genes from each patient. Also shown are module associations with different clinical characteristics of malaria severity. Some modules contain all human or all P. falciparum genes, whereas others contain genes from both species, reflecting possible co-regulation between host and parasite. [CREDIT: LEE ET AL./SCIENCE TRANSLATIONAL MEDICINE]