Contents

Research Articles

• Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

  By Hyun Jae Lee, Athina Georgiadou, Michael Walther, Davis Nwakanma, Lindsay B. Stewart, Michael Levin, Thomas D. Otto, David J. Conway, Lachlan J. Coin, Aubrey J. Cunnington

  Science Translational Medicine27 Jun 2018 Full AccessRestricted Access

  Host and parasite RNA sequencing is combined with parasite load estimates to reveal mechanisms associated with human severe malaria.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection

  By Benjamin Y. Winer, Elham Shirvani-Dastgerdi, Yaron Bram, Julie Sellau, Benjamin E. Low, Heath Johnson, Tiffany Huang, Gabriela Hrebikova, Brigitte Heller, Yael Sharon, Katja Giersch, Sherif Gerges, Kathleen Seneca, Mihai-Alexandru Pais, Angela S. Frankel, Luis Chiriboga, John Cullen, Ronald G. Nahass, Marc Lutgehetmann, Jared E. Toettcher, Michael V. Wiles, Robert E. Schwartz, Alexander Ploss

  Science Translational Medicine27 Jun 2018 Full AccessRestricted Access

  An inbred mouse model for HDV infection can be used to study virally induced immune responses and for testing antiviral therapeutics.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy

  By Thomas C. Thannickal, Joshi John, Ling Shan, Dick F. Swaab, Ming-Fung Wu, Lalini Ramanathan, Ronald McGregor, Keng-Tee Chew, Marcia Cornford, Akihiro Yamanaka, Ayumu Inutsuka, Rolf Fronczek, Gert Jan Lammers, Paul F. Worley, Jerome M. Siegel

  Science Translational Medicine27 Jun 2018 Full AccessRestricted Access

  Heroin addiction is accompanied by an increase in detected hypocretin (orexin) neurons, and in narcoleptic mice deficient in these neurons, morphine can reverse cataplexy.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas

  By Natalia Saenz-Ponce, Rachael Pillay, Lilia Merida de Long, Trinayan Kashyap, Christian Argueta, Yosef Landesman, Mehlika Hazar-Rethinam, Samuel Boros, Benedict Panizza, Maarten Jacquemyn, Dirk Daelemans, Orla M. Gannon, Nicholas A. Saunders

  Science Translational Medicine27 Jun 2018 Full AccessRestricted Access

  Selective mislocalization of E2F7 in head and neck cancers drives anthracycline resistance and can be reversed.

  • Editor's Summary
  • Abstract
  • Full Text
  • PDF
  • Supplementary Materials