Research ArticleCancer

Afatinib restrains K-RAS–driven lung tumorigenesis

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Science Translational Medicine  20 Jun 2018:
Vol. 10, Issue 446, eaao2301
DOI: 10.1126/scitranslmed.aao2301

Article Information

vol. 10 no. 446

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  • Received for publication June 29, 2017
  • Resubmitted March 19, 2018
  • Accepted for publication May 11, 2018
  • .

Author Information

  1. Herwig P. Moll1,
  2. Klemens Pranz2,
  3. Monica Musteanu3,
  4. Beatrice Grabner2,
  5. Natascha Hruschka2,
  6. Julian Mohrherr2,
  7. Petra Aigner2,
  8. Patricia Stiedl2,
  9. Luka Brcic4,
  10. Viktoria Laszlo5,6,
  11. Daniel Schramek7,8,9,
  12. Richard Moriggl2,10,11,
  13. Robert Eferl12,
  14. Judit Moldvay13,
  15. Katalin Dezso14,
  16. Pedro P. Lopez-Casas3,
  17. Dagmar Stoiber2,15,
  18. Manuel Hidalgo3,
  19. Josef Penninger7,
  20. Maria Sibilia12,
  21. Balázs Győrffy16,
  22. Mariano Barbacid3,
  23. Balázs Dome5,6,13,17,
  24. Helmut Popper4 and
  25. Emilio Casanova1,2,*
  1. 1Department of Physiology, Center of Physiology and Pharmacology and Comprehensive Cancer Center (CCC), Medical University of Vienna, AT-1090 Vienna, Austria.
  2. 2Ludwig Boltzmann Institute for Cancer Research, AT-1090 Vienna, Austria.
  3. 3Spanish National Cancer Research Centre, E-28029 Madrid, Spain.
  4. 4Institute of Pathology, Medical University of Graz, AT-8036 Graz, Austria.
  5. 5Division of Thoracic Surgery, Department of Surgery and CCC, Medical University of Vienna, AT-1090 Vienna, Austria.
  6. 6Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, AT-1090 Vienna, Austria.
  7. 7Institute of Molecular Biotechnology of the Austrian Academy of Sciences, AT-1030 Vienna, Austria.
  8. 8Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, ON-M5G 1X5 Toronto, Ontario, Canada.
  9. 9Department of Molecular Genetics, University of Toronto, ON-M5S 1A8 Toronto, Ontario, Canada.
  10. 10Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Medical University of Vienna, AT-1210 Vienna, Austria.
  11. 11Medical University of Vienna, AT-1090 Vienna, Austria.
  12. 12Institute of Cancer Research, Medical University of Vienna and CCC, AT-1090 Vienna, Austria.
  13. 13Department of Tumor Biology, National Korányi Institute of Pulmonology, Semmelweis University, HU-1122 Budapest, Hungary.
  14. 14First Department of Pathology and Experimental Cancer Research, Semmelweis University, HU-1122 Budapest, Hungary.
  15. 15Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, AT-1090 Vienna, Austria.
  16. 16MTA TK Lendület Cancer Biomarker Research Group, Institute of Enzymology and Second Department of Pediatrics, Semmelweis University, HU-1122 Budapest, Hungary.
  17. 17Department of Thoracic Surgery, National Institute of Oncology and Semmelweis University, HU-1122 Budapest, Hungary.
  1. *Corresponding author. Email: emilio.casanova{at}


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