Contents

13 June 2018
Vol 10, Issue 445

About The Cover

Cover image expansion

ONLINE COVER Victory over Vibrio. Despite protective vaccines and effective rehydration therapies, Vibrio cholerae, the pathogen causing cholera, continues to ravage certain parts of the world. In a pair of papers and an accompanying Focus by Hall, this issue reports on two new cholera interventions derived from engineered bacteria. Mao et al. observed that lactic acid produced by a common probiotic protected infant mice from V. cholerae challenge, and they added a cholera-sensing mechanism to the probiotic to detect breakthrough infection. Hubbard et al. attenuated a contemporary cholera strain to create a live vaccine (depicted as blue bacteria) that protected infant rabbits from V. cholerae challenge (red bacteria) within one day, which could be particularly helpful during outbreaks. [CREDIT: A. KITTERMAN/SCIENCE TRANSLATIONAL MEDICINE]