13 June 2018
Vol 10, Issue 445
  • Focus

    • Curbing cholera

      Colonization of the gut by virulent Vibrio cholerae is suppressed by probiotic-like activity of a live cholera vaccine candidate and Lactococcus lactis in two animal models (Hubbard et al. and Mao et al., this issue).

  • Research Articles

    • A live vaccine rapidly protects against cholera in an infant rabbit model

      An engineered cholera vaccine candidate mediates colonization resistance and disease protection within 1 day in an infant rabbit model.

    • NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension

      TGF-β–independent oxidative modification of NEDD9 at Cys18 promotes vascular fibrosis and the pathobiology of pulmonary arterial hypertension.

    • Statins enhance efficacy of venetoclax in blood cancers

      Statins cooperate with proapoptotic drugs to enhance tumor killing in blood cancers.

  • Editors' Choice

    • ELK-1: A molecular substrate of depression

      Converging data from depressed patients and rodent chronic stress models implicate ELK-1, a stress-related transcription factor, in the pathophysiology of depression.

    • Precision medicine in a dish

      Pancreatic ductal adenocarcinoma patient–derived organoids might predict treatment response and precision medicine for cancer patients.

About The Cover

Cover image expansion

ONLINE COVER Victory over Vibrio. Despite protective vaccines and effective rehydration therapies, Vibrio cholerae, the pathogen causing cholera, continues to ravage certain parts of the world. In a pair of papers and an accompanying Focus by Hall, this issue reports on two new cholera interventions derived from engineered bacteria. Mao et al. observed that lactic acid produced by a common probiotic protected infant mice from V. cholerae challenge, and they added a cholera-sensing mechanism to the probiotic to detect breakthrough infection. Hubbard et al. attenuated a contemporary cholera strain to create a live vaccine (depicted as blue bacteria) that protected infant rabbits from V. cholerae challenge (red bacteria) within one day, which could be particularly helpful during outbreaks. [CREDIT: A. KITTERMAN/SCIENCE TRANSLATIONAL MEDICINE]