An increase in LRRK2 suppresses autophagy and enhances Dectin-1–induced immunity in a mouse model of colitis

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Science Translational Medicine  06 Jun 2018:
Vol. 10, Issue 444, eaan8162
DOI: 10.1126/scitranslmed.aan8162

Article Information

vol. 10 no. 444

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  • Received for publication August 22, 2016
  • Resubmitted May 23, 2017
  • Accepted for publication December 19, 2017

Author Information

  1. Tetsuya Takagawa1,2,
  2. Atsushi Kitani2,
  3. Ivan Fuss2,
  4. Beth Levine3,
  5. Steven R. Brant4,
  6. Inga Peter5,
  7. Masaki Tajima2,
  8. Shiro Nakamura1 and
  9. Warren Strober2,*
  1. 1Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Nishinomiya 663-8501, Japan.
  2. 2Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  3. 3Departments of Internal Medicine and Microbiology, Center for Autophagy Research, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  4. 4Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins School of Medicine, and Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA.
  5. 5Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  1. *Corresponding author. Email: wstrober{at}


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Jun 20185585261486
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