Research ArticleCancer

Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance

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Science Translational Medicine  30 May 2018:
Vol. 10, Issue 443, eaah6816
DOI: 10.1126/scitranslmed.aah6816

Article Information

vol. 10 no. 443

PubMed: 
Print ISSN: 
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History: 
  • Received for publication July 20, 2016
  • Resubmitted January 15, 2018
  • Accepted for publication April 23, 2018
  • .

Author Information

  1. Yu Shi1,2,
  2. Olga A. Guryanova2,
  3. Wenchao Zhou2,
  4. Chong Liu3,
  5. Zhi Huang2,
  6. Xiaoguang Fang2,
  7. Xiuxing Wang4,
  8. Cong Chen1,2,
  9. Qiulian Wu4,
  10. Zhicheng He1,
  11. Wei Wang3,
  12. Wei Zhang5,
  13. Tao Jiang5,
  14. Qing Liu1,
  15. Yaping Chen1,
  16. Wenying Wang1,
  17. Jingjing Wu1,
  18. Leo Kim4,6,
  19. Ryan C. Gimple4,6,
  20. Hua Feng7,
  21. Hsiang-Fu Kung1,
  22. Jennifer S. Yu2,8,9,
  23. Jeremy N. Rich4,
  24. Yi-Fang Ping1,*,
  25. Xiu-Wu Bian1,* and
  26. Shideng Bao2,9,*
  1. 1Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing 400038, China.
  2. 2Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  3. 3Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
  4. 4Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
  5. 5Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
  6. 6Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
  7. 7Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  8. 8Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH 44195, USA.
  9. 9Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
  1. *Corresponding author. Email: baos{at}ccf.org (S.B.); bianxiuwu{at}263.net (X.-W.B.); pingyifang{at}126.com (Y.-F.P.)

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