Research ArticleNeuroscience

Adult rat myelin enhances axonal outgrowth from neural stem cells

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Science Translational Medicine  23 May 2018:
Vol. 10, Issue 442, eaal2563
DOI: 10.1126/scitranslmed.aal2563

Editor's Summary

Myelin has been suggested to block regeneration of adult axons after spinal cord injury in mammals. In a new study, Poplawski et al. report that the outgrowth of axons from transplants of rat neural stem cells into sites of spinal cord injury in rat recipients may be stimulated by myelin, allowing axons to extend through the site of spinal cord injury. This growth depended in part on a cell adhesion molecule found on the surface of rodent NPCs called neuronal growth regulator 1 (Negr1). The finding that myelin may be able to stimulate neural repair in rodents suggests that this versatile substance should be investigated further for its potential to improve neural stem cell therapy for spinal cord injury.

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