A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent

Noemi Gioelli; Federica Maione; Chiara Camillo; Michela Ghitti; Donatella Valdembri; Noemi Morello; Marie Darche; Lorena Zentilin; Gabriella Cagnoni; Yaqi Qiu; Mauro Giacca; Maurizio Giustetto; Michel Paques; Ilaria Cascone; Giovanna Musco; Luca Tamagnone; Enrico Giraudo; Guido Serini

doi:10.1126/scitranslmed.aah4807

Research ArticleCancer

A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent

Noemi Gioelli¹,²,*,
Federica Maione²,³,*,
Chiara Camillo¹,²,
Michela Ghitti⁴,
Donatella Valdembri¹,²,
Noemi Morello⁵,
Marie Darche⁶,
Lorena Zentilin⁷,
Gabriella Cagnoni¹,²,
Yaqi Qiu²,³,
Mauro Giacca⁷,
Maurizio Giustetto⁵,⁸,
Michel Paques⁹,¹⁰,
Ilaria Cascone⁶,
Giovanna Musco ⁴,
Luca Tamagnone ¹,²,†,
Enrico Giraudo ²,³,†,‡ and
Guido Serini ¹,²,†,‡

¹Department of Oncology, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy.
²Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Torino, Italy.
³Department of Science and Drug Technology, University of Torino, 10125 Torino, Italy.
⁴Biomolecular NMR Unit, IRCCS Ospedale San Raffaele, 20132 Milano, Italy.
⁵Department of Neuroscience, University of Torino School of Medicine, 10126 Torino, Italy.
⁶Growth, Reparation and Tissue Regeneration Laboratory, ERL-CNRS 9215, University of Paris-Est, 94000 Créteil, France.
⁷Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy.
⁸National Institute of Neuroscience-Italy, 10126 Torino, Italy.
⁹Vision Institute, Sorbonne University, UPMC University of Paris 06, INSERM, CNRS, 75012 Paris, France.
¹⁰Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, INSERM-DHOS CIC 503, 75012 Paris, France.

↵‡Corresponding author. Email: guido.serini{at}ircc.it (G.S.); enrico.giraudo{at}ircc.it (E.G.)

↵* These authors contributed equally to this work as first authors.
↵† These authors contributed equally to this work as senior authors.

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Science Translational Medicine 23 May 2018:
Vol. 10, Issue 442, eaah4807
DOI: 10.1126/scitranslmed.aah4807

Noemi Gioelli

Department of Oncology, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy.Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Torino, Italy.

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Federica Maione

Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Torino, Italy.Department of Science and Drug Technology, University of Torino, 10125 Torino, Italy.

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ORCID record for Federica Maione

Chiara Camillo

Department of Oncology, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy.Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Torino, Italy.

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Michela Ghitti

Biomolecular NMR Unit, IRCCS Ospedale San Raffaele, 20132 Milano, Italy.

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Donatella Valdembri

Department of Oncology, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy.Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Torino, Italy.

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Noemi Morello

Department of Neuroscience, University of Torino School of Medicine, 10126 Torino, Italy.

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Marie Darche

Growth, Reparation and Tissue Regeneration Laboratory, ERL-CNRS 9215, University of Paris-Est, 94000 Créteil, France.

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Lorena Zentilin

Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy.

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Gabriella Cagnoni

Department of Oncology, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy.Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Torino, Italy.

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Yaqi Qiu

Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Torino, Italy.Department of Science and Drug Technology, University of Torino, 10125 Torino, Italy.

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Mauro Giacca

Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy.

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Maurizio Giustetto

Department of Neuroscience, University of Torino School of Medicine, 10126 Torino, Italy.National Institute of Neuroscience-Italy, 10126 Torino, Italy.

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Michel Paques

Vision Institute, Sorbonne University, UPMC University of Paris 06, INSERM, CNRS, 75012 Paris, France.Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, INSERM-DHOS CIC 503, 75012 Paris, France.

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Ilaria Cascone

Growth, Reparation and Tissue Regeneration Laboratory, ERL-CNRS 9215, University of Paris-Est, 94000 Créteil, France.

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Giovanna Musco

Biomolecular NMR Unit, IRCCS Ospedale San Raffaele, 20132 Milano, Italy.

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Luca Tamagnone

Department of Oncology, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy.Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Torino, Italy.

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Enrico Giraudo

Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Torino, Italy.Department of Science and Drug Technology, University of Torino, 10125 Torino, Italy.

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For correspondence: guido.serini@ircc.it enrico.giraudo@ircc.it

Guido Serini

Department of Oncology, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy.Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Torino, Italy.

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For correspondence: guido.serini@ircc.it enrico.giraudo@ircc.it

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A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent

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