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A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent

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Science Translational Medicine  23 May 2018:
Vol. 10, Issue 442, eaah4807
DOI: 10.1126/scitranslmed.aah4807

Article Information

vol. 10 no. 442

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History: 
  • Received for publication July 2, 2016
  • Resubmitted November 20, 2017
  • Accepted for publication April 26, 2018
  • .

Author Information

  1. Noemi Gioelli1,2,*,
  2. Federica Maione2,3,*,
  3. Chiara Camillo1,2,
  4. Michela Ghitti4,
  5. Donatella Valdembri1,2,
  6. Noemi Morello5,
  7. Marie Darche6,
  8. Lorena Zentilin7,
  9. Gabriella Cagnoni1,2,
  10. Yaqi Qiu2,3,
  11. Mauro Giacca7,
  12. Maurizio Giustetto5,8,
  13. Michel Paques9,10,
  14. Ilaria Cascone6,
  15. Giovanna Musco4,
  16. Luca Tamagnone1,2,,
  17. Enrico Giraudo2,3,, and
  18. Guido Serini1,2,,
  1. 1Department of Oncology, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy.
  2. 2Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Torino, Italy.
  3. 3Department of Science and Drug Technology, University of Torino, 10125 Torino, Italy.
  4. 4Biomolecular NMR Unit, IRCCS Ospedale San Raffaele, 20132 Milano, Italy.
  5. 5Department of Neuroscience, University of Torino School of Medicine, 10126 Torino, Italy.
  6. 6Growth, Reparation and Tissue Regeneration Laboratory, ERL-CNRS 9215, University of Paris-Est, 94000 Créteil, France.
  7. 7Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy.
  8. 8National Institute of Neuroscience-Italy, 10126 Torino, Italy.
  9. 9Vision Institute, Sorbonne University, UPMC University of Paris 06, INSERM, CNRS, 75012 Paris, France.
  10. 10Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, INSERM-DHOS CIC 503, 75012 Paris, France.
  1. Corresponding author. Email: guido.serini{at}ircc.it (G.S.); enrico.giraudo{at}ircc.it (E.G.)
    • * These authors contributed equally to this work as first authors.

    • These authors contributed equally to this work as senior authors.

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